Molecular Basis of Endocrine Regulation by Orphan Nuclear Receptor Small Heterodimer Partner

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  • CHANDA Dipanjan
    Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University
  • PARK Jeong-Hoh
    Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University
  • CHOI Hueng-Sik
    Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University

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Nuclear receptors (NRs) are a unique superfamily of transcription factors (TFs) which are involved in and play a crucial role in almost all aspects of mammalian physiology. Small Heterodimer Partner (SHP; NR0B2), an exceptional member of this superfamily of NRs, have been identified as a key regulatory factor of the transcription of a variety of genes involved in diverse metabolic pathways, and are thereby an important factor in a variety of physiological functions. Since its discovery a decade ago, considerable progress has been made in the elucidation of the underlying mechanism by which SHP regulates various metabolic processes, and the results of previous studies support its importance in the maintenance of metabolic homeostasis. In this review, we have evaluated the current state of understanding of the molecular mechanisms and the resultant physiological interpretations governed by SHP.<br>

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  • Endocrine Journal

    Endocrine Journal 55 (2), 253-268, 2008

    一般社団法人 日本内分泌学会

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