Hypothyroidism Results in Small Dense LDL Independent of IRS Traits and Hypertriglyceridemia

• ABBAS Jasem M. K.

  Division of Clinical Biochemistry, Mubarak Al-Kabeer Hospital

• CHAKRABORTY Jagadish

  Departments of Medical Laboratory Sciences, Kuwait University

• AKANJI Abayomi O.

  Departments of Pathology, Kuwait University

• DOI Suhail A. R.

  Division of Endocrinology, Mubarak Al-Kabeer Hospital

抄録

There is evidence of an association between hypothyroidism and coronary heart disease. We decided to look at the relationship between hypothyroidism and LDL subclasses' pattern including small, dense LDL to define a biochemical basis for better management of the CHD risk of these patients. We utilized a case-control design to evaluate differences in lipid parameters between cases and controls. Univariate analysis revealed that many factors were associated with LDL particle size. Binary logistic regression however revealed that only thyroid status and serum triglyceride (TG) levels were independently associated with LDL particle size. Results from this study support an independent association between LDL particle size phenotype and both plasma TG concentrations and thyroid status. After adjusting for TG levels, other insulin resistance syndrome (IRS) traits were not associated with LDL size phenotype, suggesting that the IRS related sdLDL is linked most strongly to alterations in TG levels.<br>

収録刊行物

• Endocrine Journal

  Endocrine Journal 55 (2), 381-389, 2008

  一般社団法人 日本内分泌学会

キーワード

• Hypothyroidism
• Small dense LDL
• Atherosclerosis

詳細情報

• CRID: 1390282681275571328
• NII論文ID: 10021265836
• NII論文ID: 130004443404
• NII書誌ID: AA10901436
• DOI: 10.1507/endocrj.k07e-065
• ISSN: 13484540
• ISSN: 09188959
• Web Site: http://www.jstage.jst.go.jp/article/endocrj/55/2/55_K07E-065/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008234294
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
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