ACQUIRED HEMOPHILIA A DISCOVERED WITH A HEMORRHAGIC DUODENAL ULCER THAT HAD DIFFICULTY WITH ENDOSCOPIC HEMOSTASIS, REPORT A CASE
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- MURATA Atsuhiko
- Department of Gastroenterology, Aso Iizuka Hospital
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- AKAHOSHI Kazuya
- Department of Gastroenterology, Aso Iizuka Hospital
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- NAKAMURA Kazuhiko
- Department of Medicine and Bioregulatory Science , Graduate School of Medical Sciences, Kyushu University.
Bibliographic Information
- Other Title
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- 出血を繰り返す十二指腸潰瘍を契機に診断された後天性血友病Aの1例
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Abstract
A 77-year-old woman was admitted to our hospital because of a hemorrhagic duodenal ulcer that had difficulty with endoscopic hemostasis and hemorrhage from right subclavian vein in which was inserted a central venous catheter. Coagulation tests showed a great prolongation of activated partial thromboplastin time (APTT) on admission . After admission, severe bleeding from the ulcer appeared, we performed endoscopic therapy by hypertonic saline epinephrine injection. Hemorrhage from right subclavian vein was stopped by astriction. Laboratory studies showed an extremely low factor uG activity and the presence of a very high titer factor uG inhibitor. She was diagnosed as acquired hemophilia A, and treated with oral prednisone, cyclophosphamide and intravenous methylprednisolone pulse therapy. After treat ment, activated partial thromboplastin time normalized and factor uG inhibitor disappeared . In case of gastrointestinal bleeding that had difficulty with endoscopic hemostasis, we should pay attention to the possibility of acquired hemophilia A .
Journal
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- GASTROENTEROLOGICAL ENDOSCOPY
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GASTROENTEROLOGICAL ENDOSCOPY 50 (2), 217-222, 2008
Japan Gastroenterological Endoscopy Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001204220103168
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- NII Article ID
- 130004255159
- 10021272094
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- NII Book ID
- AN00192102
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- ISSN
- 18845738
- 03871207
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed