RELATION BETWEEN RESPIRATORY SUPPRESSION FROM SEDATION DURING ENDOSCOPY AND VITAL CAPACITY

• TOMIKI Yuichi

  Department of Coloproctological Surgery, Juntendo University School of Medicine

• SHINMURA Koji

  Department of Coloproctological Surgery, Juntendo University School of Medicine

• KASAMAKI Shinji

  Department of Coloproctological Surgery, Juntendo University School of Medicine

• TERAI Kiyoshi

  Department of Coloproctological Surgery, Juntendo University School of Medicine

• MAEDA Tsutomu

  Department of Coloproctological Surgery, Juntendo University School of Medicine

• TAKEDA Ryohei

  Department of Coloproctological Surgery, Juntendo University School of Medicine

• TAKAHASHI Makoto

  Department of Coloproctological Surgery, Juntendo University School of Medicine

• YAGINUMA Yukihiro

  Department of Coloproctological Surgery, Juntendo University School of Medicine

• SAKAMOTO Kazuhiro

  Department of Coloproctological Surgery, Juntendo University School of Medicine

• NAKAJIMA Takashi

  Department of Coloproctological Surgery, Juntendo University School of Medicine

• KAMANO Toshiki

  Department of Coloproctological Surgery, Juntendo University School of Medicine

• HAYASHIDA Yasuo

  Department of General Medicine, Juntendo University School of Medicine

Bibliographic Information

Other Title

• 内視鏡検査におけるｓｅｄａｔｉｏｎの呼吸抑制と肺活量の関係

Abstract

Background : Respiratory suppression is observed during endoscopy under sedation. If respira tory suppression can be predicted before endoscopy, incidental complications can conceivably be prevented. In the present study, we focused on the relation between respiratory suppression from sedation and lung function. Methods : A total of 211 patients underwent respiratory function tests before the surgical operation and gave written informed consent individually to participate in this study. We investigated the relation between respiratory suppression from sedation and lung function. During the endoscopic procedure, when blood oxygen saturation (Sp02) fell to below 90%, the patient was evaluated as 'respiratory suppression present'. Results : Sedation lowered Sp0₂ by an average of 6.0%, and was significantly lower than the prior to sedation blood oxygen saturation (PreSpO2). Compared to patients with Sp0₂ maintained up to 90%, patients with Sp0₂ fallen below 90% were significantly older, shorter in stature, lighter in bodyweight, and more commonly female. Furthermore, respiratory suppression from sedation was influenced by vital capacity (VC) and PreSpO₂. Multivariate analysis was performed, and the receiver operating characteristic (ROC) curve constructed for the respiratory suppression prediction model based on age, height, VC and PreSpO₂ yielded area under the curve (AUC) of 0.79. As VCpredjct can be calculated from age and height, the three variables of age, height and VC in the above model were substituted with VCpredict resulting in a two-factor model based on VCpredict and PreSpO₂. The ROC curve of the two-factor model had AUC of 0.77, which was slightly decreased but by no means inferior. Conclusion : Predicting respiratory suppression from VCpredict and PreSpO₂ is clinically rele vant with the additional benefit of simplicity.

Journal

• GASTROENTEROLOGICAL ENDOSCOPY

  GASTROENTEROLOGICAL ENDOSCOPY 50 (4), 1169-1176, 2008

  Japan Gastroenterological Endoscopy Society

Keywords

• 内視鏡/予測肺活量/呼吸抑制/sedation/肺活量

Details

• CRID: 1390001204220108416
• NII Article ID: 130004090144
• NII Article ID: 10021272749
• NII Book ID: AN00192102
• DOI: 10.11280/gee1973b.50.1169
• ISSN: 18845738
• ISSN: 03871207
• Web Site: https://search.jamas.or.jp/link/ui/2008209202
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
  • Crossref
• Abstract License Flag: Disallowed