Analysis of acute renal failure after allogeneic hematopoietic stem cell transplantation

DOI Web Site 24 References
  • Ando Minoru
    Department of Nephrology, Tokyo Metropolitan Komagome Hospital
  • Nakamura Yuya
    Department of Nephrology, Tokyo Metropolitan Komagome Hospital
  • Suzuki Hitoe
    Department of Nephrology, Tokyo Metropolitan Komagome Hospital
  • Shibuya Asuka
    Department of Nephrology, Tokyo Metropolitan Komagome Hospital

Bibliographic Information

Other Title
  • 単一施設における同種造血幹細胞移植後急性腎不全の解析
  • タンイツ シセツ ニ オケル ドウシュ ゾウケツ カンサイボウ イショクゴ キュウセイ ジンフゼン ノ カイセキ

Search this article

Abstract

Recent development of hematopoietic stem cell transplantation (HSCT) has remarkably contributed to improvement of the quality and life span of patients. However, acute renal failure (ARF), which is considered to occur frequently after HSCT, is often critical and most relevant to survival of patients. We attempted to examine the clinical characteristics of ARF in patients who were treated with allogeneic HSCT, using our own database that had been accumulated from 1998 to 2006. A retrospective analysis of 402 adult patients (239 males and 163 females) receiving transplants at Komagome Hospital was undertaken. Mean patient age was 39.9±12.5 years. ARF was defined as serum creatinine (Cr) elevation more than 1.2 mg/dL or two-fold rise in serum Cr levels. Incidence of ARF was 8.9% (36 out of 402 patients) and mortality rate of ARF patients was 52.8% (19 out of 36 patients). Mean age of ARF patients was 47.4±9.25 years, which was significantly higher than that of all HSCT patients. ARF occurred 17±14.7 days after HSCT. It was very difficult to determine a specific cause of ARF because most patients had coexisting diseases, such as drug-induced tubulo-interstitial nephritis, infections including sepsis, and acute graft versus host disease. Advanced age and high serum Cr levels at the time of HSCT were relevant to the mortality of ARF patients. Dialysis treatment was required in 9 ARF patients (9 of 36 patients : 25.0%) all of whom concomitantly developed several organ failures including heart, lung, and liver. Therefore, their mortality rate was quite high (89%). In conclusion, the incidence of ARF after HSCT was approximately 9% and its mortality rate was 52.8%. Patients who developed serious multiple organ failure required dialysis therapy and their mortality rate was extremely high.

Journal

References(24)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top