STEREOTACTIC RADIOTHERAPY FOR LUNG CANCER USING ACTIVE BREATHING CONTROL SYSTEM

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  • 能動的呼吸制御装置を用いた肺癌定位放射線治療

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Abstract

In Tohoku University Hospital, primary or metastatic lung cancers with the respiratory motion of more than 1 cm were treated with SRT (stereotactic radiotherapy) under ABC (active breathing control: ABC-SRT). The local control rate and lung toxicity treated with ABC-SRT were analyzed. The indication of ABC-SRT is as follows: tumor size in largest diameter ≤5 cm, motion distance ≥1 cm, and patient’s consent to treatment.<br>Nineteen patients (average age: 58.2 years, male 12: female 7) with 25 lesions were enrolled to ABC-SRT during March 2000 and July 2004. Patients with primary lung cancer were four, the others with metastatic cancer. Prescribed doses were 45 Gy/3 fr or 60 Gy/8 fr at the isocenter. ABC-SRT was successfully done for all patients except one patient who failed to be given the prescribed dose (only 45 Gy/6 fr were administered). In 24 lesions with complete treatment, the control rate in 1/2/4 years was 94.1%/74.0%/74.0%, respectively. In tumors <2.5 cm size in largest diameter, the control rate was 90.0%, ≥2.5 cm, 42.9%, tendency of significance (p=0.0579) was observed. One patient developed grade 2 pneumonitis (RTOG: Radiation Therapy Oncologic Group/EORTC: European Organization for Research and Treatment of Cancer), who was then orally medicated with steroid to cure. The others developed grade 0-1 pneumonitis. Although 10 of 19 patients were treated with chemotherapy, the lung toxicity was relatively light. Reduction of PTV by ABC seem to reduce the lung toxicity. In tumors <2.5 cm size in largest diameter, good control rate was acquired compared to the tumors ≥2.5 cm in size. We’re going to analyze the lung toxicity treated without ABC-SRT to compare the present results. [Article in Japanese]

Journal

  • The Journal of JASTRO

    The Journal of JASTRO 18 (2), 91-98, 2006

    Japanese Society for Therapeutic Radiology and Oncology

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