HIGH-DOSE SUPERSELECTIVE INTRA-ARTERIAL CISPLATIN AND CONCOMITANT RADIATION THERAPY FOR CARCINOMA OF THE ORAL CAVITY

DOI 2 Citations 19 References

Bibliographic Information

Other Title
  • 口腔癌に対する超選択的動注療法を併用した放射線治療の成績

Search this article

Abstract

Purpose: To evaluate the effect of high-dose superselective intra-arterial cisplatin and concomitant radiation therapy for carcinoma of the oral cavites. Methods and Materials: The subjects consisted of 18 patients with carcinoma of the oral, and cavity treated with superselective intra-arterial infusion of high dose cisplatin (100mg/body) concomitant with delivery of external beam radiotherapy (median total dose, 60.8 Gy) between 2001 and 2004. Sodium thiosulfate was administered intravenously to provide effective cisplatin neutlization. They were UICC1997 stage II-IV (stage II: 4 patients, stage III: 4 patients, stage IV: 10 patients). Patients ranged from 43-81 years of age, with a median of 60 years, and included 14 men and 4 women. A follow-up period was 6 months minimum from the atart of the radiation therapy, the median follow up period at 28 months. Results: The three-year overall survival rate was 71%. The three-year disease free rate and local control rate were 60% and 65%, respectively. Three-year local control rate of the T2-3 was achieved at 83%, and that for T4 at 50%. There was borderline significant difference in local control rate between T2-3 and T4 (p = 0.05). Conclusion: We conclude that the high-dose superselective intra-arterial cisplatin and concomitant radiation therapy provides effective results in organ preservation for cancer of oral cavitces. Further studies are also required to determine the validity of this method.

Journal

  • The Journal of JASTRO

    The Journal of JASTRO 19 (1), 11-15, 2007

    Japanese Society for Therapeutic Radiology and Oncology

Citations (2)*help

See more

References(19)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top