下咽頭癌症例の臨床的検討 Clinical Analysis of Hypopharyngeal Cancer

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Fifty patients with squamous cell carcinoma of the hypopharynx were treated at Hiroshima Red Cross Hospital and Atomic-bomb Survivors Hospital from September 1993 to August 2005. Of these 50 cases, 45 were male and 5 were female and the average of age was 64.4. All cases were pathologically diagnosed as squamous cell carcinoma. The primary lesion was located in the pyriform sinus in 26 cases, the postcricoid in 13 cases, the posterior pharyngeal wall in 10 cases and was unclassified in 1 case. Our guideline for the treatment of hypopharyngeal cancer is a combination of radiotherapy, chemotherapy and surgery. The schedule of combination therapy is as follows: all patients were treated with irradiation of 40Gy (and chemotherapy if possible). When the primary lesion responded almost completely to 40Gy irradiation, the patient subsequently received full-dose irradiation. If a complete response was not obtained, the patient underwent radical surgery. Of 50 patients, 44 patients could be treated radically in this schedule. As a result, almost all of the patients treated with surgery were especially advanced cases. The cause-specific 5-year survival rate of all patient was 46.0%. There were significant differences in suvival between T3 stage and T4 stage, between below N1 stage and beyond N2 stage. Of 15 patients who died of disease, 9 (60%) died of distant metastasis. Eight of these 9 patients were diagnosed with N2b stage. We thought that our guideline for the treatment of hypopharyngeal cancer was reasonable because of the increased possibility of preservation of larynx and that patients with multiple metastasis to cervical lymph nodes should receive chemotherapy strictly.

収録刊行物

  • 耳鼻咽喉科臨床

    耳鼻咽喉科臨床 101(3), 207-214, 2008-03-01

    耳鼻咽喉科臨床学会

参考文献:  18件中 1-18件 を表示

被引用文献:  3件中 1-3件 を表示

各種コード

  • NII論文ID(NAID)
    10021294147
  • NII書誌ID(NCID)
    AN00107089
  • 本文言語コード
    JPN
  • 資料種別
    NOT
  • ISSN
    00326313
  • NDL 記事登録ID
    9404488
  • NDL 雑誌分類
    ZS43(科学技術--医学--耳鼻咽喉科学)
  • NDL 請求記号
    Z19-421
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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