書誌事項
- タイトル別名
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- Fasudil administration combined with a steroid for the treatment of idiopathic sudden sensorineural hearing loss.-effect of Rho-kinase inhibitor on cochlear ischemia-
- effect of Rho-kinase inhibitor on cochlear ischemia
- 内耳循環障害とRhoキナーゼの関連
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Fasudil, a potent Rho-kinase inhibitor, has been reported to reverse the endothelin-induced vasoconstriction of the spiral modiolar artery in the gerbil cochlea. We previously demonstrated that both endothelin receptors and endothelin-converting enzymes are expressed in the rat cochlea and that the serum endothelin levels in patients with sudden sensorineural hearing loss (SSHL) were significantly increased before steroid treatment. Since one subgroup of SSHL is believed to arise from vasoconstriction and vasospasm of the spiral modiolar artery ultimately causing ischemic stroke of the cochlea, we conducted a clinical investigation of fasudil (Rho-kinase inhibitor) combined with a steroid for the treatment of SSHL by preventing the inner ear ischemia induced by endothelin. Nine out of ten SSHL patients (90%) who received intravenous infusion of fasudil (9 days×30mg twice/day) showed complete or significant recovery in the level of hearing. The average hearing level was 72.7dB (n=10) before fasudil treatment, 44.9dB at the end of fasudil treatment (9 days after), and 31.9dB at the final evaluation. These results indicate that idiopathic SSHL could be caused by endothelin-induced vasoconstriction and vasospasm of the spiral modiolar artery of the cochlea, and that the fasudil administration combined with a steroid may be a novel potent treatment option for SSHL.
収録刊行物
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- AUDIOLOGY JAPAN
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AUDIOLOGY JAPAN 50 (2), 144-149, 2007
一般社団法人 日本聴覚医学会
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詳細情報 詳細情報について
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- CRID
- 1390001204841753344
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- NII論文ID
- 130003863794
- 10021299472
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- NII書誌ID
- AN00000347
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- ISSN
- 18837301
- 03038106
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
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- 使用不可