Photodynamic Therapy for Airway Stenosis using Rabbit Models

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  • Nakagishi Yoshinori
    Department of Medical Engineering, National Defense Medical College Department of Surgery, National Defense Medical College
  • Morimoto Yuji
    Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College
  • Fujita Masanori
    Department of Surgery, National Defense Medical College
  • Morimoto Noriko
    Department of Otolaryngology, National Center for Child Health and Development
  • Ozeki Yuichi
    Department of Surgery, National Defense Medical College
  • Maehara Tadaaki
    Department of Surgery, National Defense Medical College
  • Kikuchi Makoto
    Department of Medical Engineering, National Defense Medical College

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Other Title
  • 肉芽性気道狭窄に対する光線力学的治療
  • ニクガセイ キドウ キョウサク ニ タイスル コウセン リキガクテキ チリョウ

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Abstract

Background Airway stenosis in childhood is resistant to conventional treatments. We examined whether photodynamic therapy (PDT), which is one of the less invasive therapeutic modalities, is effective for airway stenosis. Methods Airway stenosis rabbit models were made by scraping the mucosal membrane of the trachea. After the stenosis-induced rabbits were intravenously administered with Photofrin, the tissue concentrations of Photofrin were measured. The stenosis-induced animals were treated by PDT using Photofrin, and then bronchoscopic examination was repeatedly carried out to observe the status of tracheal stenosis. Results Photofrin concentration in the granulation tissue was four-times higher than that in the intact trachea and 10-times higher than that in the other examined tissues. PDT ameliorated the degree of airway stenosis and reduced respiratory stridor. Conclusions Photofrin preferentially accumulated in lesions of airway stenosis and PDT was effective for relief of airway stenosis. These findings suggest that PDT has potential as a novel therapeutic method for airway stenosis originating from granulation tissue.

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