Histopathological Risk Factors for Lymph Node Metastases of Submucosal Colorectal Cancer by LYVE-1 Immunohistochemistry

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  • Saito N.
    Department of Surgery, Toho University Medical Center, Omori Hospital

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  • 大腸粘膜下層浸潤癌のリンパ節転移におけるＬＹＶＥ‐１抗体を用いたリンパ管侵襲の組織学的検討

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Abstract

Purpose: Lymphatic invasion is an important predictor for lymph node (LN) metastasis in colorectal cancer. However, it is difficult to identify vessels precisely by the current ways of stain. The purpose of this study is to make it clear the significance of lymphatic invasion as a predictor of LN metastasis by using LYVE-1 immunohistochemistry as an indicator of lymphatic vessels to evaluate the utility of lymphatic invasion the significance of lymphatic invasion.<br> Objects and Methods: The immunostain by LYVE-1 was carried out to 58 cases with colorectal cancer showing submucosal invasion including 17 cases with LN metastasis.<br> Result: According to the univariate logistic regression analysis, four factors were regarded as the predictive factors on LN metastasis: the tumordifferentiation (p=0.003), the depth of submucosal invasion of the primary tumor (p=0.011), budding (p=0.005), and lymphatic invasion by LYVE-1 immunohistochemistry (p=0.0003). On the other hand, according to the multivariate logistic regression analysis, only the lymphatic invasion was a predictor on LN metastasis.<br> Conclusion: The result of this study indicates the important of lymphatic invasion and the utility of the LYVE-1 immunohistochemistry.<br>

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