The Usefulness of Moisturizers for Maintenance of Remission in Atopic Dermatitis

• Kawashima Makoto

  Department of Dermatology, Tokyo Women’s Medical University

• Hayashi Nobukazu

  Department of Dermatology, Tokyo Women’s Medical University

• Nogita Toshitatsu

  Shinjuku Minamiguchi Dermatological Clinic

• Yanagisawa Kyoko

  Iderea Skin Clinic Daikanyama

• Mizuno Atsuko

  Yuraku-cho Clinic of Dermatology

Bibliographic Information

Other Title

• アトピー性皮膚炎の寛解維持における保湿剤の有用性の検討
• アトピーセイ ヒフエン ノ カンカイ イジ ニ オケル ホシツザイ ノ ユウヨウセイ ノ ケントウ

Abstract

The usefulness of moisturizers (heparinoid preparation) for maintenance of remission in atopic dermatitis (AD) was studied in a randomized controlled trial (RCT). A total of 65 patients who applied a heparinoid preparation twice daily for two weeks to their dry skin after topical steroid treatment were randomly assigned to either the heparinoid preparation continuous application group or the untreated control group. All patients were followed up for six weeks at most. Inflammation relapsed in 12.5% of the heparinoid preparation group and 39.4% of the control group, indicating significant inhibition of inflammation relapse in the heparinoid preparation group (χ²=6.0841, p=0.0136). A significant difference was observed in the period of no inflammation between the two groups (log-rank test, p=0.0117), suggesting that continuous application of the heparinoid preparation extends the period to inflammation relapse. This study demonstrates the usefulness of moisturizers for sustained remission of AD.

Journal

• The Japanese Journal of Dermatology

  The Japanese Journal of Dermatology 117 (7), 1139-1145, 2007

  Japanese Dermatological Association

Keywords

• atopic dermatitis
• moisturizer
• randomized controlled trial (RCT)
• heparinoid
• remission

Details

• CRID: 1390001205735784192
• NII Article ID: 130004708531
• NII Article ID: 10021303898
• NII Book ID: AN00196602
• DOI: 10.14924/dermatol.117.1139
• ISSN: 13468146
• ISSN: 0021499X
• NDL BIB ID: 8871262
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8871262
• Web Site: https://search.jamas.or.jp/link/ui/2007304131
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • CiNii Articles
• Abstract License Flag: Disallowed