Comparisons of Clinical Efficacy of Oral Terbinafine for Toenail Onychomycosis between Different Toes and Different Clinical Types: Two Regimens of Intermittent Administration

• Okuda Chozaburo

  Section of Dermatology, Saiseikai Sanjo Hospital

• Ito Masaaki

  Department of Dermatology, Niigata University Graduate School of Medical and Dental Sciences

Bibliographic Information

Other Title

• 趾爪白癬に対する経口抗真菌薬テルビナフィンの部位別・病型別治癒率の検討（第1報）　―2種類の間歇投与法の比較を含めて―
• シソウ ハクセン ニ タイスル ケイコウ コウシンキンヤク テルビナフィン ノ ブイベツ ビョウケイベツ チユリツ ノ ケントウ ダイ 1ポウ 2シュルイ ノ カンケツ トウヨホウ ノ ヒカク オ フクメテ

Abstract

〔Methods〕Patients with toenail onychomycosis were divided into 2 groups; one group (intermittent group) was administered 125mg terbinafine a day for 2 weeks in every 4 weeks, and the other group (pulse group) was administered 250mg a day for 1 week in every 4 weeks, for up to 48 weeks. The clinical features of the lesions were sorted into 2 clinical types ; the S-type (lateral edge, streak, spike, or lamellar splitting onychomycosis) and the U-type (other onychomycosis). At 52 weeks, cure rates were calculated separately for each toe and for each clinical type. Background factors that might affect the cure rates were statistically analyzed. 〔Results〕Cure rates in the intermittent group were 71.4% for the U-type of 1st toenails, 65.2% for the S-type of 1st toenails, 100% for the U-type of 2nd-5th toenails, and 87.5% for the S-type of 2nd-5th toenails. In the pulse group, the respective cure rates were 79.2%, 75.0%, 93.3%, and 100%. No statistically significant differences were detected between the two regimens. However, 1st toenails cured at significantly lower rates (65–79%), compared with the extremely high cure rates (87.5–100%) of the 2nd-5th toenails. There were no significant differences in cure rates between the different types of clinical features. There were also no significant differences in occurrence rates of adverse events between the two regimens. 〔Conclusion〕Intermittent oral administration of terbinafine seems sufficiently useful for treatment of toenail onychomycosis, although the cure rate for 1st toenails is significantly lower than that for the 2nd-5th toenails.

Journal

• The Japanese Journal of Dermatology

  The Japanese Journal of Dermatology 117 (10), 1603-1610, 2007

  Japanese Dermatological Association

Keywords

• toenail onychomycosis
• terbinafine
• intermittent administration
• cure rates
• statistics

Details

• CRID: 1390001205736117248
• NII Article ID: 130004708475
• NII Article ID: 10021304338
• NII Book ID: AN00196602
• DOI: 10.14924/dermatol.117.1603
• ISSN: 13468146
• ISSN: 0021499X
• NDL BIB ID: 8927279
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8927279
• Web Site: https://search.jamas.or.jp/link/ui/2007346004
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • CiNii Articles
• Abstract License Flag: Disallowed