ロタウイルス感染症の下痢黒毛和種子牛における血清ハプトグロビンおよびα1-酸性糖タンパク質濃度と血清添加によるリンパ球幼若化能の抑制

• 岡本 光司

  山口大学大学院連合獣医学研究科 鹿児島大学農学部

• 阿久沢 正夫

  鹿児島大学農学部

• 出口 栄三郎

  鹿児島大学農学部

書誌事項

タイトル別名

• Changes of Serum Haptoglobin and α1-Acid Glycoprotein Concentrations and Effects of Serum on Lymphocyte Blastogenesis in Calves with Rota Virus Infection
• Changes of Serum Haptoglobin and アルファ 1-Acid Glycoprotein Concentrations and Effects of Serum on Lymphocyte Blastogenesis in Calves with Rota Virus Infection

抄録

To clarify the changes of serum haptoglobin (HP) and α1-acid glycoprotein (α1-AGP) concentrations and the effects of serum in new born calves with diarrhea on lymphocyte blastogenesis, eight healthy Japanese Black calves and 24 Japanese Black calves during the 12-24 h after the onset of diarrhea with Rota virus infection, 3-35d of age, were studied. Though serum HP was not detected in healthy calves, it did appear in the serum of all calves with diarrhea (599±414μg/ml). On the other hand, there was no significant difference between normal calves (398±100μg/ml) and calves with diarrhea (441±104μg/ml) in serum α1-AGP concentration. The lymphocyte blastogenesis induced by concanavalin A in peripheral mononuclear cells, isolated from one clinically healthy 13-month-old Japanese Black castrated male steer, was significantly suppressed compared to those from normal calves and the steer by adding heat-inactivated (56°C for 30min) sera from calves with diarrhea (P<0.01). Furthermore, a significant negative correlation between the serum HP concentrations and serum-lymphocyte blastogenesis reaction was obtained in calves with diarrhea (R²=0.693, P<0.01). However, no significant correlation was observed between the serum α1-AGP concentrations and the serum-lymphocyte blastogenesis reaction (R²=0.001). These results indicate that HP appears in the serum of newborn calves with Rota virus infection within 12-24h after the onset of diarrhea and that lymphocyte blastogenesis induced by T-cell mitogen is inhibited by serum from calves with Rota virus infection in a dosedependent manner of serum HP.

収録刊行物

• 日本畜産学会報

  日本畜産学会報 69 (11), 988-993, 1998

  公益社団法人 日本畜産学会

キーワード

• Acute phase proteins
• Haptoglobin
• Newborn calf
• Rota virus infection
• Suppression of lymphocyte blastogenesis

詳細情報

• CRID: 1390001205196027776
• NII論文ID: 130000743268
• NII論文ID: 10021724618
• NII論文ID: 10020393843
• NII書誌ID: AN00195188
• DOI: 10.2508/chikusan.69.988
• ISSN: 18808255
• ISSN: 00215309
• ISSN: 1346907X
• NDL書誌ID: 4666536
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4666536
• Web Site: https://search.jamas.or.jp/link/ui/1999089496
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可