Detection of genetic toxicity in secondary metabolites of Fusarium strains isolated from domestic animal feeds

• ARAKAWA K.

  Division of Paracitology, National Institute of Infectious Diseases

• TANAKA N.

  Division of Genetic Toxicology, Hadano Research Institute, Food and Drag Safety Center

• TAKATORI K.

  Division of Microbiology, National Institute of Health Sciences

• SAWADA T.

  Laboratory of Veterinary Microbiology, Nippon Veterinary and Life Science University

Bibliographic Information

Other Title

• 飼料から分離したＦｕｓａｒｉｕｍ代謝産物の遺伝毒性

Abstract

Metabolites of 8 species 53 strains of Fusarium isolated from domestic animal feeds were tested in Salmonella mutagenicity test with and without metabolic activation. Mutagenic activity was detected on crude extracts of 5 species 13 strains of them; F. graminearum, F. nivale, F. tricinctum, F. semitectum, and F. oxysporum. From the result of thin layer chromatography, it seems that those mutagenic metabolites were the same compound. Moreover, the highest mutagenic activity extract was tested in chromosome aberrations in human lymphocytes and dominant lethal test in mice. It was detected chromatid type aberrations; gap and brake, in human lymphocytes, and induction of dominant lethality on late spermatids and sperms in mice.

Journal

• JSM Mycotoxins

  JSM Mycotoxins 56 (2), 57-64, 2006

  Japanese Society of Mycotoxicology

Keywords

• <i>Fusarium</i>
• <i>Salmonella</i>
• mutagenicity
• Ames test
• chromosome aberration test
• dominant lethal test

Details

• CRID: 1390282679760354816
• NII Article ID: 10021919843
• NII Book ID: AN00334513
• DOI: 10.2520/myco.56.57
• ISSN: 18810128
• ISSN: 02851466
• Web Site: https://agriknowledge.affrc.go.jp/RN/2030752092
• Web Site: https://search.jamas.or.jp/link/ui/2007176015
• Text Lang: ja
• Data Source:
  • JaLC
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed