No Association Between <i>INSIG2</i> Gene rs7566605 Polymorphism and Being Overweight in Japanese Population

• Yasuharu Tabara

• Ryuichi Kawamoto

• Haruhiko Osawa

• Jun Nakura

• Hideichi Makino

• Tetsuro Miki

• Katsuhiko Kohara

抄録

Obesity is a complex trait reflecting numerous genetic and environmental factors. Recently, a common genetic polymorphism (rs7566605) associated with a higher BMI was found in proximity to the insulin induced protein 2 ( INSIG2 ) gene, with replication in four unrelated populations living in Western countries. We investigated the susceptibility to the polymorphism amongst the general Japanese population ( n = 1976). The frequency of appearance of the single‐nucleotide polymorphism (SNP) in the Japanese (G allele; 0.652, C allele; 0.348) was not different from that found in subjects of European origin as reported previously. However, the BMI levels in each of these genotypes did not differ significantly (GG; 23 ± 3, GC; 24 ± 3, CC; 24 ± 3 kg/m 2 , P = 0.906). In a separate analysis according to sex (male; P = 0.462, female; P = 0.879), age decade (40s; P = 0.057, 50s; P = 0.998, 60s; P = 0.622, 70s; 0.425, respectively), and tertiles of the BMI (1st; P = 0.409, 2nd; P = 0.088, 3rd; P = 0.780), the differences did not achieve statistical significance. The frequency of obesity did not differ among the genotypes (25 kg/m 2 ; 30.3, 30.8, 28.2%, P = 0.729, 30 kg/m 2 ; 2.9, 3.8, 2.8%, P = 0.549). No associations were also observed for related plasma markers; high‐molecular weight (HMW) adiponectin ( P = 0.510), high‐sensitive C‐reactive protein ( P = 0.788), resistin ( P = 0.937) and homeostasis of minimal assessment of insulin resistance ( P = 0.634). These results indicate a lack of association between SNP rs7566605 and being overweight among the Japanese (in the middle‐aged and elderly population).

収録刊行物

• Obesity

  Obesity 16 (1), 211-215, 2008-01

  Wiley

キーワード

• Nutrition and Dietetics
• Endocrinology
• Endocrinology, Diabetes and Metabolism
• Medicine (miscellaneous)

詳細情報

• CRID: 1360002216818017536
• NII論文ID: 10021929593
• DOI: 10.1038/oby.2007.25
• ISSN: 1930739X
• ISSN: 19307381
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1038%2Foby.2007.25
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1038/oby.2007.25
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  • CiNii Articles
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