Bone Induction by Biomimetic Functionally Graded Hydroxyapatite with rhBMP-2 on Rat Skull Periosteum
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- HINO Jun
- Division of Oral and Maxillofacial Surgery, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido
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- MURATA Masaru
- Division of Oral and Maxillofacial Surgery, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido
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- AKAZAWA Toshiyuki
- Department of Materials Technology,Hokkaido Industrial Research Institute
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- TAZAKI Junichi
- Division of Reconstructive Surgery for Oral and Maxillofacial Region,Department of Human Biology and Pathophysiology, School of Dentistry,Health Sciences University of Hokkaido
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- ARISUE Makoto
- Division of Oral and Maxillofacial Surgery, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido
Bibliographic Information
- Other Title
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- 生体模倣傾斜機能アパタイト/rhBMP-2複合体によるラット頭部骨膜上骨誘導
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Abstract
The objective of this study was to estimate bone induction by a bioabsorbable hydroxyapatite block (functionally graded hydroxyapatite: fg-HAp, 3×3×3 mm)/rhBMP-2 (5 μg) on rat skull periosteum, the absorption of fg-HAp, compared with non-absorbable hydroxyapatite (BONECERAM®). In the fg-HAp/BMP-2, bone formation started in the outer layer of the ceramics at 1 week after implantation and induced bone was found in the middle part at 4 weeks. In both the fg-HAp alone and the fg-HAp/BMP-2 groups, body fluid permeated into the bulk of fg-HAp scaffold and then fg-HAp block was gradually fragmented by autodegradation and bio-absorption. On the other hand, in the non-absorbable HAp/BMP-2, bone was found locally in the surface layer of the HAp at 4 weeks. In the fg-HAp alone and the non-absorbable HAp alone, bone formation never occurred in this model.<br/> Therefore, our fg-HAp is an bio-absorbable ceramic and the fg-HAp/BMP-2 supra-periosteal implant might be a superior bone reservoir system.
Journal
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- Journal of Japanese Society of Oral Implantology
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Journal of Japanese Society of Oral Implantology 21 (2), 327-337, 2008
Japanese Society of Oral Implantology
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Details 詳細情報について
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- CRID
- 1390282680485698304
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- NII Article ID
- 130003398213
- 10021952776
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- NII Book ID
- AN10072606
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- ISSN
- 21879117
- 09146695
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed