Calcium Metabolism in Hypertension.

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  • McCarron David A
    Division of Nephrology, Hypertension and Clinical Pharmacology, Oregon Health Sciences University

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Abstract

Pathological alterations in calcium metabolism are a factor in abnormal blood pressure regulation in some humans. A consistent nutrient/blood pressure association has been demonstrated in epidemiological studies, the strength of which has been acknowledged by leading authorities in the field of nutritional epidemiology. Thus, in patients with mild to moderate hypertension, dietary calcium intake should be assessed, and where appropriate, they should be encouraged to maintain intake levels of 800 to 1000mg/day. More importantly, for normal subjects at risk of developing high blood pressure, inadequate intake of dietary calcium should be avoided. It is clear that the maintenance of the recommended daily calcium intake is essential for optimal blood pressure control as well as bone and cardiovascular health. As the accumulated evidence suggests, it is the prevention of calcium deficiency that should be strived for in patients with essential hypertension or individuals at risk of developing this all-too-common medical disorder. Adequate intake should be promoted of not only calcium, but also potassium, magnesium, phosphorus and essential fatty acids. The published scientific data summarized here support this conclusion as well as the implementation of strategies to effect such an outcome in order to improve cardiovascular health in humans.

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