The role of cytokine signaling in pathophysiology for spinal cord injury

DOI Web Site 参考文献85件
  • Okada Seiji
    SSP stem cell Unit, Kyushu University School of Medicine, Fukuoka, Japan Department of Orthopaedic Surgery, Kyushu University School of Medicine, Fukuoka, Japan
  • Nakamura Masaya
    Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan
  • Renault-Mihara Francois
    Department of Physiology, Keio University School of Medicine, Tokyo, Japan
  • Mukaino Masahiko
    Department of Physiology, Keio University School of Medicine, Tokyo, Japan
  • Saiwai Hirokazu
    SSP stem cell Unit, Kyushu University School of Medicine, Fukuoka, Japan Department of Orthopaedic Surgery, Kyushu University School of Medicine, Fukuoka, Japan
  • Toyama Yoshiaki
    Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan
  • Iwamoto Yukihide
    Department of Orthopaedic Surgery, Kyushu University School of Medicine, Fukuoka, Japan
  • Okano Hideyuki
    Department of Physiology, Keio University School of Medicine, Tokyo, Japan

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Although many cytokines are involved in the pathophysiology of spinal cord injury (SCI), the role of each cytokine remains elusive. Many lines of evidence have indicated that the excess inflammation elicited by pro-inflammatory cytokines exhibit neuronal and glial toxicity and that administration of several anti-inflammatory drugs can prevent this extensive secondary injury. Besides targeting secondary injury, modulating cytokine signaling is also an attractive therapeutic strategy as differentiational regulator for neural stem/progenitor cells. Here, we review the role of cytokine signaling which are both deleterious and beneficial in the pathophysiology for spinal cord injury, with an emphasis on the role of IL-6 signaling.

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