Influence of Aging and Menopause on Postprandial Lipoprotein Responses in Healthy Adult Women

DOI Web Site PubMed 被引用文献11件 参考文献88件
  • Nabeno Yuka
    Division of Nutrition and Health, School and Graduate School of Life Studies, Sugiyama Jogakuen University.
  • Fukuchi Yoshiko
    Division of Nutrition and Health, School and Graduate School of Life Studies, Sugiyama Jogakuen University.
  • Matsutani Yasuko
    Division of Nutrition and Health, School and Graduate School of Life Studies, Sugiyama Jogakuen University.
  • Naito Michitaka
    Division of Nutrition and Health, School and Graduate School of Life Studies, Sugiyama Jogakuen University.

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Aim: To analyze the influence of menopause and age on postprandial lipoprotein responses in healthy adult women.<BR>Method: Twenty-seven healthy young and middle-aged pre- and postmenopausal female volunteers aged 21-53 y were enrolled. They ingested OFTT cream(Jomo, Takasaki, Japan). Fasting and postprandial blood samples were obtained for up to 6 h, and serum concentrations of lipoproteins were analyzed.<BR>Results: In the postprandial phase, serum triglycerides(TG), remnant-like particle(RLP)-TG(RLP-TG), RLP-cholesterol(RLP-C), and TG-rich lipoprotein-TG(TRL-TG)concentrations in all groups peaked after 2 h. After 4 h, the TG, RLP-C, RLP-TG and TRL-TG concentrations in the young women returned to the fasting concentrations. However, at 6 h, these parameters in the pre- and postmenopausal women had barely returned to the fasting concentrations.<BR>Conclusion: The present results suggest that:(1)the magnitude of postprandial TG concentrations is dependent on age, but not on menopause;(2)clearance of remnant lipoproteins is delayed with age in pre- and postmenopausal women compared to young women, and(3)menopause is associated with an increase of RLP-C, but may not influence LDL particle size.

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