Genetic Association between Aldehyde Dehydrogenase 2 (ALDH2) Variation and High-Density Lipoprotein Cholesterol (HDL-C) Among Non-Drinkers in Two Large Population Samples in Japan

DOI Web Site 7 Citations 60 References
  • Wada Manabu
    Departments of Neurology, Hematology, Metabolism, Endocrinology, and Diabetology, Faculty of Medicine, Yamagata University.
  • Daimon Makoto
    Departments of Neurology, Hematology, Metabolism, Endocrinology, and Diabetology, Faculty of Medicine, Yamagata University.
  • Emi Mitsuru
    Departments of Neurology, Hematology, Metabolism, Endocrinology, and Diabetology, Faculty of Medicine, Yamagata University. HuBit Genomix Research Institute.
  • Iijima Hiroshi
    Departments of Neurology, Hematology, Metabolism, Endocrinology, and Diabetology, Faculty of Medicine, Yamagata University. HuBit Genomix Research Institute.
  • Sato Hidenori
    Departments of Neurology, Hematology, Metabolism, Endocrinology, and Diabetology, Faculty of Medicine, Yamagata University. HuBit Genomix Research Institute.
  • Koyano Satoru
    Departments of Neurology, Hematology, Metabolism, Endocrinology, and Diabetology, Faculty of Medicine, Yamagata University. HuBit Genomix Research Institute.
  • Tajima Katsushi
    Departments of Neurology, Hematology, Metabolism, Endocrinology, and Diabetology, Faculty of Medicine, Yamagata University.
  • Kawanami Toru
    Departments of Neurology, Hematology, Metabolism, Endocrinology, and Diabetology, Faculty of Medicine, Yamagata University.
  • Kurita Keiji
    Departments of Neurology, Hematology, Metabolism, Endocrinology, and Diabetology, Faculty of Medicine, Yamagata University.
  • Hunt Steven C
    Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah School of Medicine.
  • Hopkins Paul N
    Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah School of Medicine.
  • Kubota Isao
    Departments of Cardiology, Pulmonology, and Nephrology, Faculty of Medicine, Yamagata University.
  • Kawata Sumio
    Department of Gastroenterology, Faculty of Medicine, Yamagata University.
  • Kato Takeo
    Departments of Neurology, Hematology, Metabolism, Endocrinology, and Diabetology, Faculty of Medicine, Yamagata University.

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Abstract

Aim:Moderate alcohol consumption appears to confer some protection against coronary heart disease, which is related to an increase in high-density lipoprotein cholesterol (HDL-C). The genotype of aldehyde dehydrogenase 2 (ALDH2) is closely related to alcohol metabolism but a relationship between ALDH2 genotypes and HDL-C levels has not been proven. We undertook a large-scale correlation study between HDL-C levels and ALDH2 genotype among Japanese non-drinkers to investigate the possibility that HDL-C levels could be associated with ALDH2 genotype.<BR>Methods:We examined a population-based sample of Japanese subjects who do not consume alcohol (n=1,736) to investigate the relationship between ALDH2 genotypes and lipid or lipoprotein concentrations in serum. We also investigated whether an association between ALDH2 genotype and HDL-C levels might be found in another Japanese sample.<BR>Results:In an independent population of non-drinkers from a different geographical region of Japan, HDL-C levels were associated with the same ALDH2 genotypes.<BR>Conclusions:The results of the present study suggested that genetic variation in the ALDH2 gene can influence HDL-C levels, independent of alcohol consumption.

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