Farnesol as a Quorum-sensing Molecule in Candida albicans

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  • Cho Tamaki
    Section of Infection Biology, Department of Functional Bioscience, Fukuoka Dental College
  • Aoyama Toshihiro
    Department of Electronic and Information Engineering, Suzuka National College of Technology
  • Toyoda Mika
    Section of Infection Biology, Department of Functional Bioscience, Fukuoka Dental College
  • Nakayama Hironobu
    Department of Chemistry and Biochemistry, Suzuka National College of Technology
  • Chibana Hiroji
    Medical Mycology Research Center, Chiba University
  • Kaminishi Hidenori
    Section of Infection Biology, Department of Functional Bioscience, Fukuoka Dental College
  • A Calderone Richard
    Georgetown University Medical Center, Department of Microbiology and Immunology

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Other Title
  • Ｃａｎｄｉｄａ　ａｌｂｉｃａｎｓのｑｕｏｒｕｍ‐ｓｅｎｓｉｎｇ分子ｆａｒｎｅｓｏｌ
  • Candida albicansのquorum-sensing分子farnesol
  • Candida albicans ノ quorum-sensing ブンシ farnesol

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Abstract

Farnesol is one of the quorum sensing molecules of Candida albicans. In this report, we discuss the effects of farnesol on: 1. growth of Candida albicans in vitro and in vivo; 2. the incorporation of biomolecules into the cell wall of Candida albicans; and 3. cytokine expression by the immune system. Our results indicate genes of Candida albicans expressed at an early stage of quorum-sensing. Half of these genes are known and two-thirds of known genes are up-regulated by two types of transcription factors.

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