General Anesthesia Based on Recent Mechanism Hypothesis

• MASHIMO Takashi

  Department of Anesthesiology and Intensive Care Medicine, Graduate School of Medicine, Osaka University

• TAKAHASHI Ayako

  Department of Anesthesiology and Intensive Care Medicine, Graduate School of Medicine, Osaka University

Bibliographic Information

Other Title

• 最近の麻酔メカニズム仮説から考える全身麻酔

Abstract

  GABA is the principal inhibitory neurotransmitter in the central nerve system. It mediates fast synaptic inhibition by interaction with the GABA_A receptor. GABA_A receptors are ligand-gated ion channels that are modulated by a large number of anesthetics. Over the past decade, in addition to conventional forms of transient synaptic responses that underlie phasic conductances, a tonic conductance has been identified in several brain regions. Tonic inhibition of this type refers to the continuous activation of high affinity, slowly desensitizing GABA_A receptors by low concentrations of ambient GABA. For many years, enhancement of fast synaptic inhibition was widely thought to be the primary mechanism underlying the actions of many anesthetics. Recently, attention has turned to tonic inhibition, as this conductance has more sensitivity to anesthetic actions than phasic inhibition. Here we summarize several recent discoveries related to the effects of anesthetics on GABA_A receptors.

Journal

• THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA

  THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA 29 (1), 78-84, 2009

  THE JAPAN SOCIETY FOR CLINICAL ANESTHESIA

Keywords

• General anesthesia
• GABA_A receptor
• Tonic current

Details

• CRID: 1390282679736608000
• NII Article ID: 10023975480
• NII Article ID: 130004449824
• NII Book ID: AN00330159
• DOI: 10.2199/jjsca.29.78
• ISSN: 13499149
• ISSN: 02854945
• Web Site: https://search.jamas.or.jp/link/ui/2009101879
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed