幻肢痛に対する大脳皮質刺激療法のメカニズム解析 Mechanistic analysis of motor cortex stimulation for phantom limb pain

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   Phantom limb pain and other deafferentation pain are characterized by changes in cortical processing and organization (cortical reorganization), poor response to conventional treatments. Whereas several studies reported a close relationship between imagery movements of the amputated or paralyzed limb and the intractable pain, the alterations in the motor cortex related to the imagery movements has not yet been explored in detail. Here, we studied the electrocorticogram (ECoG) of sensorimotor cortex in deafferentation pain to reveal the relationship between some imagery movement tasks and the dynamical pattern of ECoG during the tasks. A clear correlation between the ECoG and imagery movements was observed in a patient who well responded to motor cortex stimulation (MCS). On the other hand, there was little correlation between them in a patient who did not respond to MCS. For the former patient, the optimal stimulation site for MCS located around the primary motor cortex, where the pattern of ECoG well differentiated among types of imagery movements. We will discuss the relation between imagery movements and the effects of MCS.

収録刊行物

  • Pain research : the journal of the Japanese Society for the Study of Pain = 日本疼痛学会誌

    Pain research : the journal of the Japanese Society for the Study of Pain = 日本疼痛学会誌 23(1), 27-34, 2008-01-31

    日本疼痛学会

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各種コード

  • NII論文ID(NAID)
    10024130730
  • NII書誌ID(NCID)
    AN10195934
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    09158588
  • データ提供元
    CJP書誌  J-STAGE 
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