小児結核感染診断におけるQuantiFERON<SUP>®</SUP>TB-2Gの有用性に関する検討

• 徳永 修

  国立病院機構南京都病院小児科

• 濱谷 舟

  国立病院機構南京都病院小児科

• 宮野前 健

  国立病院機構南京都病院小児科

• 樋口 一恵

  結核予防会結核研究所抗酸菌レファレンスセンター免疫検査科

• 原田 登之

  結核予防会結核研究所抗酸菌レファレンスセンター免疫検査科

書誌事項

タイトル別名

• Performance of QunatiFERON<SUP>®</SUP> TB-2G in childhood active tuberculosis and latent tuberculosis

抄録

The whole blood interferon-γ assay, QuantiFERON^® TB-2G (QFT) was undertaken in 89 children with a risk of latent tuberculosis (TB) infection (LTBI) or active TB disease to estimate the efficacy of this assay for the diagnosis of LTBI and active TB disease in children. QFT tested before starting anti-TB chemotherapy was positive in all five cases with active TB disease (2-16 years), suggesting that QFT might be a sensitive and useful diagnostic tool also in childhood active TB disease cases. About 40%cases with very close contacts with smear-positive contagious TB patients were QFT positive, but no cases were positive in 3 children under 1 year. Mitogen (PHA) control IFN-γ responses in infantile cases were significantly lower than cases older than 6 years (p=0 .001), and IFN-γ responses to EAST-6 or CFP-10 stimulus were significantly correlated with age in LTBI or active TB disease cases with positive QFT response (Spearman's coefficient=0.691, p<0.05). QFT may have lower sensitivity in diagnosing LTBI in young children, especially infants, than adult cases .

収録刊行物

• 日本小児呼吸器疾患学会雑誌

  日本小児呼吸器疾患学会雑誌 18 (2), 127-136, 2007

  日本小児呼吸器疾患学会

キーワード

• 小児結核
• 結核感染

詳細情報

• CRID: 1390282679396853504
• NII論文ID: 10024137338
• NII書誌ID: AN10297832
• DOI: 10.5701/jjpp.18.127
• ISSN: 21853754
• ISSN: 09183876
• Web Site: https://search.jamas.or.jp/link/ui/2008139449
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可