Uptake Behavior of Thallium-201 in Hindlimb Muscles of Rats

• Inaoka Pleiades Tiharu

  Department of Impairment Study, Graduate Course of Rehabilitation Science, Division of Health Sciences, Graduate School of Medical Science, Kanazawa University

• Tachino Katsuhiko

  Department of Impairment Study, Graduate Course of Rehabilitation Science, Division of Health Sciences, Graduate School of Medical Science, Kanazawa University

• Amano Ryohei

  Department of Forefront Medical Technology, Graduate Course of Medical Science and Technology, Division of Health Sciences, Graduate School of Medical Science, Kanazawa University

• Yamazaki Toshiaki

  Department of Impairment Study, Graduate Course of Rehabilitation Science, Division of Health Sciences, Graduate School of Medical Science, Kanazawa University

• Yokogawa Masami

  Department of Impairment Study, Graduate Course of Rehabilitation Science, Division of Health Sciences, Graduate School of Medical Science, Kanazawa University

• Tanaka Shoji

  Department of Impairment Study, Graduate Course of Rehabilitation Science, Division of Health Sciences, Graduate School of Medical Science, Kanazawa University

抄録

[Purpose] We aimed to examine the uptake and retention behavior of the radioisotope thallium-201(²⁰¹Tl) in 5 hindlimb muscles, the soleus (Sol), plantaris (Pla), gastrocnemius (Gast), extensor digitorum longus (EDL), and tibialis anterior (TA). [Subjects] Male Wistar rats. [Methods] Three experiments were perfomed: ²⁰¹Tl uptake and retention as a function of time after intravenous injection; uptake and retention under general anesthesia and in the conscious state; Analysis in hindlimb suspension model rats. [Results] There were significant differences between the uptake rates of Sol and other muscles. The uptake rates of the conscious group muscles were significantly higher than those of the unconscious group; the ratio of Sol/EDL uptake was approximately 2.5 for the conscious animals, although that for unconscious animals was 1.3. In hindlimb-suspended rats, no significant differences between Sol and EDL uptake rates were seem throughout the course of the experiment. [Conclusion] In summary, rat skeletal muscles are very sensitive to uptake and retention of ²⁰¹Tl and are markedly dependent on time from injection, state of consciousness and on the muscular trophicity. The results of the present study suggest that ²⁰¹Tl may contribute to physiological evaluation of muscle in rehabilitation science.<br>

収録刊行物

• Ｊ　Ｐｈｙｓ　Ｔｈｅｒ　Ｓｃｉ

  Ｊ　Ｐｈｙｓ　Ｔｈｅｒ　Ｓｃｉ 20 (2), 117-122, 2008

  理学療法科学学会

キーワード

• Hindlimb suspension
• Thallium-201
• Muscle

詳細情報

• CRID: 1390001204329467392
• NII論文ID: 10024159198
• NII書誌ID: AA10798949
• DOI: 10.1589/jpts.20.117
• ISSN: 21875626
• ISSN: 09155287
• Web Site: http://www.jstage.jst.go.jp/article/jpts/20/2/20_2_117/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2009027577
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可