Proteomic analysis of lactosylceramide-enriched membrane microdomains

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  • Yanagida Mitsuaki
    Institute for Environmental and Gender-specific Medicine, Juntendo University Graduate School of Medicine
  • Iwabuchi Kazuhisa
    Institute for Environmental and Gender-specific Medicine, Juntendo University Graduate School of Medicine Infection control Nursing, Juntendo University Graduate School of Health Care and Nursing

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  • ラクトシルセラミドの集積する生体膜マイクロドメインのプロテオーム解析
  • ラクトシルセラミドの集積する生体膜マイクロドメインのプロテオーム解析[含 英語文]
  • ラクトシルセラミド ノ シュウセキスル セイタイ マク マイクロドメイン ノ プロテオーム カイセキ ガン エイゴブン

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Abstract

Membrane microdomains (lipid rafts) are cholesterol- and glycosphingolipid-enriched lipid domains, which are involved in various cellular responses connecting the intracellular and extracellular environments. We investigated the neutrophilic function focusing on lactosylceramide-enriched membrane microdomains on the neutrophilic cell plasma membrane. Although membrane microdomains in neutrophils are known to be involved in neutrophilic functions, such as phagocytosis, the molecular mechanisms of action remain to be elucidated. In this review, strategies for comprehensive analysis of the microdomain-associated proteins for investigating the molecular mechanisms of action of these domains are described.<br>

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