Development of Nanoparticle Array Method by Using DNA Sequence Recognition Peptide

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  • 塩基配列認識ペプチドを用いたナノ粒子配列法の開発
  • エンキ ハイレツ ニンシキ ペプチド オ モチイタ ナノ リュウシ ハイレツホウ ノ カイハツ

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Abstract

As nanotechnology has been developed, various nanoparticles and elemental device have been studied intensively. These studies suggest that new materials can be created by regular arranging of nanoparticles. However, a method for the arranging has not been developed sufficiently. We tried to arrange by using DNA molecules and the DNA sequences recognition peptide-conjugated nanoparticles. To achieve this goal, we investigated the following topics: 1) sample preparation of DNA sequence recognition peptide-conjugated nanoparticles; 2) complex formation of DNA and DNA sequence recognition peptide conjugated nanoparticles; 3) observation and evaluation of them by Atomic Force Microscope (AFM) techniques. We succeeded in the conjugation of the nanoparticle and the DNA sequence recognition peptide, the formation of the DNA and the peptide-conjugated nanoparticle complexes, and thearrangement of the nanoparticles in a target place on DNA.<br>

Journal

  • KOBUNSHI RONBUNSHU

    KOBUNSHI RONBUNSHU 65 (7), 493-495, 2008

    The Society of Polymer Science, Japan

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