Function of Clock Genes: Influence of Medication for Bronchial Asthma on Circadian Gene

DOI Web Site 被引用文献3件 参考文献63件
  • Burioka Naoto
    Division of Medical Oncology and Molecular Respirology, Faculty of Medicine, Tottori University, Japan
  • Fukuoka Yasushi
    Division of Medical Oncology and Molecular Respirology, Faculty of Medicine, Tottori University, Japan
  • Takata Miyako
    Division of Medical Oncology and Molecular Respirology, Faculty of Medicine, Tottori University, Japan
  • Endo Masahiro
    Division of Medical Oncology and Molecular Respirology, Faculty of Medicine, Tottori University, Japan
  • Miyata Masanori
    Division of Medical Oncology and Molecular Respirology, Faculty of Medicine, Tottori University, Japan
  • Chikumi Hiroki
    Division of Medical Oncology and Molecular Respirology, Faculty of Medicine, Tottori University, Japan
  • Tomita Katsuyuki
    Division of Medical Oncology and Molecular Respirology, Faculty of Medicine, Tottori University, Japan
  • Kodani Masahiro
    Division of Medical Oncology and Molecular Respirology, Faculty of Medicine, Tottori University, Japan
  • Touge Hirokazu
    Division of Medical Oncology and Molecular Respirology, Faculty of Medicine, Tottori University, Japan
  • Takeda Kenichi
    Division of Medical Oncology and Molecular Respirology, Faculty of Medicine, Tottori University, Japan
  • Sumikawa Takashi
    Division of Medical Oncology and Molecular Respirology, Faculty of Medicine, Tottori University, Japan
  • Yamaguchi Kousuke
    Division of Medical Oncology and Molecular Respirology, Faculty of Medicine, Tottori University, Japan
  • Ueda Yasuto
    Division of Medical Oncology and Molecular Respirology, Faculty of Medicine, Tottori University, Japan
  • Nakazaki Hirofumi
    Division of Medical Oncology and Molecular Respirology, Faculty of Medicine, Tottori University, Japan
  • Suyama Hisashi
    Division of Medical Oncology and Molecular Respirology, Faculty of Medicine, Tottori University, Japan
  • Yamasaki Akira
    Division of Medical Oncology and Molecular Respirology, Faculty of Medicine, Tottori University, Japan
  • Sano Hiroyuki
    Department of Respiratory Medicine Allergology, Kinki University School of Medicine, Japan
  • Igishi Tadashi
    Division of Medical Oncology and Molecular Respirology, Faculty of Medicine, Tottori University, Japan
  • Shimizu Eiji
    Division of Medical Oncology and Molecular Respirology, Faculty of Medicine, Tottori University, Japan

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タイトル別名
  • Circadian Rhythms in the CNS and Peripheral Clock Disorders: Function of Clock Genes: Influence of Medication for Bronchial Asthma on Circadian Gene

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Bronchial asthma is a chronic inflammatory disorder of the airways, in which inflammation causes bronchial hyper-responsiveness and flow limitation in the presence of various stimuli. Pulmonary function in asthmatic patients frequently deteriorates between midnight and early morning, which has suggested a role for chronotherapy. Although relationships between bronchial asthma and the function of clock genes remain unclear, some medications given for asthma such as glucocorticoids or β2-adrenoceptor agonists may influence clock genes in vivo. In our studies of clock gene mRNA expressions in human bronchial epithelial cells in vitro and peripheral blood cells in vivo, we demonstrated that glucocorticoid or β2-adrenoceptor agonist treatment strongly induced human Per1 mRNA expression both in vitro and in vivo. Human peripheral blood cells provide a useful indication of peripheral clock gene mRNA expression in vivo.<br>

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