Improvement of Postischemic Dopaminergic Dysfunction by Edaravone, a Free Radical Scavenger

• Akiyama Yoshinori

  Department of Neurosurgery, Tenri Hospital, Japan

• Miwa Soichi

  Department of Cellular Pharmacology, Hokkaido University Graduate School of Medicine, Japan

Abstract

Effects of a free radical scavenger, edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), on ischemia/reperfusion-induced dysfunctions of rat striatal dopaminergic neurons were examined using in vivo brain microdialysis. During transient forebrain ischemia, dopamine levels in dialysates were elevated 140-fold above controls but rapidly recovered after reperfusion. The increase in dopamine levels induced by high K⁺ stimulation after reperfusion was far smaller than that of the controls. Pretreatment with edaravone but not post-treatment dose-dependently improved the response to high K⁺ but not the massive dopamine increase during ischemia. These results suggest that free radicals produced during ischemia play more important roles in ischemia/reperfusion-induced dysfunctions of dopaminergic neurons.<br>

Journal

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 104 (1), 99-102, 2007

  The Japanese Pharmacological Society

Keywords

• transient forebrain ischemia
• dopamine release
• edaravone

Details

• CRID: 1390282680151888512
• NII Article ID: 10024314147
• NII Book ID: AA11806667
• DOI: 10.1254/jphs.sc0060259
• ISSN: 13478648
• ISSN: 13478613
• NDL BIB ID: 8737774
• Web Site: http://id.ndl.go.jp/bib/8737774
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8737774
• Web Site: https://search.jamas.or.jp/link/ui/2007287980
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed