A High-Sodium Diet in Streptozotocin-Induced Diabetic Rats Impairs Endothelium-Derived Hyperpolarizing Factor-Mediated Vasodilation

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Author(s)

    • Araki Mina ARAKI Mina
    • Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
    • KATAFUCHI Shiori
    • Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
    • HONDA Kenji
    • Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
    • SAITO Ryo
    • Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
    • TAKANO Yukio
    • Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University

Abstract

We examined endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation of mesenteric arteries in high-sodium loaded streptozotocin (STZ)-induced diabetic rats. The study shows that acetylcholine (ACh)-induced, EDHF-mediated relaxation is relatively maintained in STZ-induced diabetic rats, but after a high-sodium diet was given, the function was significantly impaired in STZ-induced diabetic rats.<br>

Journal

  • Journal of Pharmacological Sciences

    Journal of Pharmacological Sciences 104(4), 402-405, 2007-08-20

    The Japanese Pharmacological Society

References:  15

Cited by:  2

Codes

  • NII Article ID (NAID)
    10024315445
  • NII NACSIS-CAT ID (NCID)
    AA11806667
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    13478613
  • NDL Article ID
    8873294
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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