Tissue Plasminogen Activator Is Not Involved in Methamphetamine-Induced Neurotoxicity

DOI Web Site 参考文献25件
  • Fukakusa Ayumi
    Laboratory of Neuropsychopharmacology, Graduate School of Natural Science and Technology, Kanazawa University, Japan
  • Mizoguchi Hiroyuki
    Laboratory of Neuropsychopharmacology, Graduate School of Natural Science and Technology, Kanazawa University, Japan Futuristic Environmental Simulation Center, Research Institute of Environmental Medicine, Nagoya University, Japan
  • Koike Hiroyuki
    Laboratory of Neuropsychopharmacology, Graduate School of Natural Science and Technology, Kanazawa University, Japan
  • Nabeshima Toshitaka
    Department of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences Meijo University, Japan
  • Takuma Kazuhiro
    Laboratory of Neuropsychopharmacology, Graduate School of Natural Science and Technology, Kanazawa University, Japan
  • Yamada Kiyofumi
    Laboratory of Neuropsychopharmacology, Graduate School of Natural Science and Technology, Kanazawa University, Japan Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Japan

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To investigate the role of tissue plasminogen activator (tPA) in methamphetamine (METH)-induced dopaminergic neurotoxicity, we compared the changes in tyrosine hydroxylase (TH) and dopamine transporter (DAT) levels in the striatum after repetitive treatment of METH at 4 mg/kg among wild-type, tPA-deficient (tPA−/−), and protease activated receptor-1–deficient (PAR-1−/−) mice. METH treatment caused a marked decrease in TH and DAT levels in the striatum of those mice with a similar magnitude. No difference in METH-induced abnormal behavior and hyperthermia was observed among the three types of mice. These results suggest that neither tPA nor PAR-1 is involved in METH-induced dopaminergic neurotoxicity in vivo.<br>

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