Progress in Allergy Signal Research on Mast Cells : The Role of Histamine in Goblet Cell Hyperplasia in Allergic Airway Inflammation - a Study Using the Hdc Knockout Mouse

Access this Article

Author(s)

Abstract

Although histamine is a central mediator in the immediate allergic reaction, its role in goblet cell hyperplasia in the airway of asthma is not completely understood. This study was designed to examine the role of histamine in goblet cell hyperplasia using histamine-deficient mice (<i>Hdc</i><sup>−</sup><sup>/</sup><sup>−</sup> mice) with allergic airway inflammation. Wild-type and <i>Hdc</i><sup>−</sup><sup>/</sup><sup>−</sup> C57BL/6 mice were sensitized with ovalbumin (OVA). After two-week exposure to OVA, goblet cell hyperplasia was evaluated. Cell differentials in BALF were analyzed. The mRNAs level of <i>MUC5AC</i> and <i>Gob-5</i> gene were quantitatively determined. The number of eosinophils in BALF increased in both the wild-type mice and <i>Hdc</i><sup>−</sup><sup>/</sup><sup>−</sup> mice; however, their ratio in <i>Hdc</i><sup>−</sup><sup>/</sup><sup>−</sup> mice was significantly lower than that in the wild-type mice. The mRNA levels of <i>Gob-5</i> and <i>MUC5AC</i> and the ratio of the goblet cells in the airway epithelium were significantly increased in <i>Hdc</i><sup>−</sup><sup>/</sup><sup>−</sup> mice exposed to OVA compared to the wild-type mice under the same condition. These results suggested that histamine may play a regulatory role in goblet cell hyperplasia in allergic airway inflammation.<br>

Journal

  • Journal of Pharmacological Sciences

    Journal of Pharmacological Sciences 106(3), 354-360, 2008-03-20

    The Japanese Pharmacological Society

References:  39

Cited by:  1

Codes

  • NII Article ID (NAID)
    10024318852
  • NII NACSIS-CAT ID (NCID)
    AA11806667
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    13478613
  • NDL Article ID
    9430221
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
Page Top