The role of histamine in goblet cell hyperplasia in allergic airway inflammation: a study using the Hdc knockout mouse

• Yamauchi Kohei

  Third Department of Internal Medicine, Iwate Medical University School of Medicine, Japan

• Piao Hong Mei

  Third Department of Internal Medicine, Iwate Medical University School of Medicine, Japan Department of Respiratory Medicine, Affiliated Hospital of Yanbian University College of Medicine, China

• Nakadate Toshihide

  Third Department of Internal Medicine, Iwate Medical University School of Medicine, Japan

• Shikanai Toshiki

  Third Department of Internal Medicine, Iwate Medical University School of Medicine, Japan

• Nakamura Yutaka

  Third Department of Internal Medicine, Iwate Medical University School of Medicine, Japan

• Niisato Miyuki

  Third Department of Internal Medicine, Iwate Medical University School of Medicine, Japan

• Ito Harumasa

  Third Department of Internal Medicine, Iwate Medical University School of Medicine, Japan

• Mouri Takashi

  Third Department of Internal Medicine, Iwate Medical University School of Medicine, Japan

• Kobayashi Hitoshi

  Third Department of Internal Medicine, Iwate Medical University School of Medicine, Japan

• Maesawa Chihaya

  Second Department of Pathology, Iwate Medical University School of Medicine, Japan

• Sawai Takashi

  First Department of Pathology, Iwate Medical University School of Medicine, Japan

• Ohtsu Hiroshi

  Tohoku University Graduate School of Engineering, Japan

• Inoue Hiroshi

  Third Department of Internal Medicine, Iwate Medical University School of Medicine, Japan

書誌事項

タイトル別名

• Progress in Allergy Signal Research on Mast Cells: <br>The Role of Histamine in Goblet Cell Hyperplasia in Allergic Airway Inflammation – a Study Using the Hdc Knockout Mouse
• Progress in Allergy Signal Research on Mast Cells: The Role of Histamine in Goblet Cell Hyperplasia in Allergic Airway Inflammation – a Study Using the Hdc Knockout Mouse

抄録

Although histamine is a central mediator in the immediate allergic reaction, its role in goblet cell hyperplasia in the airway of asthma is not completely understood. This study was designed to examine the role of histamine in goblet cell hyperplasia using histamine-deficient mice (Hdc^−/− mice) with allergic airway inflammation. Wild-type and Hdc^−/− C57BL/6 mice were sensitized with ovalbumin (OVA). After two-week exposure to OVA, goblet cell hyperplasia was evaluated. Cell differentials in BALF were analyzed. The mRNAs level of MUC5AC and Gob-5 gene were quantitatively determined. The number of eosinophils in BALF increased in both the wild-type mice and Hdc^−/− mice; however, their ratio in Hdc^−/− mice was significantly lower than that in the wild-type mice. The mRNA levels of Gob-5 and MUC5AC and the ratio of the goblet cells in the airway epithelium were significantly increased in Hdc^−/− mice exposed to OVA compared to the wild-type mice under the same condition. These results suggested that histamine may play a regulatory role in goblet cell hyperplasia in allergic airway inflammation.<br>

収録刊行物

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 106 (3), 354-360, 2008

  公益社団法人 日本薬理学会

キーワード

• airway remodeling
• asthma
• Gob-5
• MUC5AC
• allergy

詳細情報

• CRID: 1390001205180906240
• NII論文ID: 10024318852
• NII書誌ID: AA11806667
• DOI: 10.1254/jphs.fm0070262
• ISSN: 13478648
• ISSN: 13478613
• NDL書誌ID: 9430221
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9430221
• Web Site: https://search.jamas.or.jp/link/ui/2008231289
• 本文言語コード: en
• データソース種別:
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