Oseltamivir Enhances Hippocampal Network Synchronization

DOI Web Site 被引用文献13件 参考文献28件
  • Usami Atsushi
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
  • Sasaki Takuya
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
  • Satoh Nobuhiro
    Laboratory of Synthetic Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
  • Akiba Takahiro
    Laboratory of Synthetic Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
  • Yokoshima Satoshi
    Laboratory of Synthetic Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
  • Fukuyama Tohru
    Laboratory of Synthetic Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
  • Yamatsugu Kenzo
    Laboratory of Synthetic Organic Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
  • Kanai Motomu
    Laboratory of Synthetic Organic Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
  • Shibasaki Masakatsu
    Laboratory of Synthetic Organic Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
  • Matsuki Norio
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
  • Ikegaya Yuji
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, Japan

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Oseltamivir, a widely used anti-influenza drug, inhibits virus neuraminidase. A mammalian homologue of this enzyme is expressed in the brain, yet the effect of oseltamivir on central neurons is largely unknown. Patch-clamp recordings ex vivo revealed that oseltamivir enhanced spike synchronization between hippocampal CA3 pyramidal cells. Time-lapse multineuron calcium imaging revealed that oseltamivir and its active metabolite evoked synchronized population bursts that recruited virtually all neurons in the network. This unique, so-far-unknown, event was attenuated by muscarinic receptor antagonist. Thus, oseltamivir is a useful tool for investigating a new aspect of neural circuit operation.<br>

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