Species Difference in the Contribution of T-Type Calcium Current to Cardiac Pacemaking as Revealed by R(−)-Efonidipine

DOI Web Site PubMed 被引用文献7件 参考文献27件
  • Tanaka Hikaru
    Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
  • Komikado Chisa
    Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
  • Namekata Iyuki
    Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
  • Nakamura Hideki
    Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
  • Suzuki Mariko
    Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
  • Tsuneoka Yayoi
    Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
  • Shigenobu Koki
    Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
  • Takahara Akira
    Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan

書誌事項

タイトル別名
  • Species Difference in the Contribution of T-Type Calcium Current to Cardiac Pacemaking as Revealed by R(-)-Efonidipine
  • Species difference in the contribution of T-type Ca2+ current to cardiac pacemaking as revealed by R(−)-efonidipine

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抄録

The contribution of the T-type Ca2+ current to cardiac pacemaking was examined in isolated right atrial tissue from the mouse, guinea pig, and rabbit using a specific blocker, R(−)-efonidipine. At 10−6 M, R(−)-efonidipine produced negative chronotropy, which was prominent in the mouse and small but significant in the guinea pig. No effect was observed in the rabbit. Microelectrode recordings revealed that R(−)-efonidipine significantly prolongs the pacemaker (phase 4) depolarization of the sinoatrial-node action potential in the mouse and guinea pig. These results provide the first pharmacological evidence that the contribution of T-type Ca2+ current to cardiac pacemaking differs among experimental animal species.<br>

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