Anticancer Photodynamic and Non-photodynamic Effects of Pterin Derivatives on a Pancreatic Cancer Cell Line

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Author(s)

Abstract

To evaluate the feasibility of two kinds of pterin derivatives, 2-(<i>N,N</i>-dimethylaminomethyleneamino)-6-formyl-3-pivaloylpteridin-4-one (DFP) and 2-(<i>N,N</i>-dimethylaminomethyleneamino)-3-pivaloylpteridin-4-one (DP), as anticancer drugs, their photodynamic and non-photodynamic effects on pancreatic cancer cell line Panc-1 cells were examined. For photodynamic effects, cell death 48 h after UV-A irradiation was more prominent in cells preloaded with DP than DFP. When cells were simply incubated for 96 h without irradiation, DFP induced cell death, while DP suppressed cell proliferation. Furthermore, DP was much more soluble in water than DFP. These findings collectively indicated that DP is more feasible as an anticancer drug than DFP.<br>

Journal

  • Journal of Pharmacological Sciences

    Journal of Pharmacological Sciences 107(2), 221-225, 2008-06-20

    The Japanese Pharmacological Society

References:  15

Codes

  • NII Article ID (NAID)
    10024321141
  • NII NACSIS-CAT ID (NCID)
    AA11806667
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    13478613
  • NDL Article ID
    9546424
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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