Functional Significance of Stage-Specific Embryonic Antigens in the Development of Preimplantation Embryos

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  • Katagiri Yohko U.
    Department of Developmental Biology, National Research Institute for Child Health and Development Core Research for Evolutional Science and Technology (CREST) of Japan Science and Technology Corporation (JST)
  • Sato Ban
    Department of Developmental Biology, National Research Institute for Child Health and Development Core Research for Evolutional Science and Technology (CREST) of Japan Science and Technology Corporation (JST)
  • Miyado Kenji
    Department of Reproductive Biology, National Research Institute for Child Health and Development
  • Akutsu Hidenori
    Department of Reproductive Biology, National Research Institute for Child Health and Development
  • Okita Hajime
    Department of Developmental Biology, National Research Institute for Child Health and Development Core Research for Evolutional Science and Technology (CREST) of Japan Science and Technology Corporation (JST)
  • Umezawa Akihiro
    Department of Reproductive Biology, National Research Institute for Child Health and Development
  • Fujimoto Junichiro
    National Research Institute for Child Health and Development Core Research for Evolutional Science and Technology (CREST) of Japan Science and Technology Corporation (JST)
  • Kiyokawa Nobutaka
    Department of Developmental Biology, National Research Institute for Child Health and Development Core Research for Evolutional Science and Technology (CREST) of Japan Science and Technology Corporation (JST)

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Other Title
  • 初期胚におけるＳｔａｇｅ‐Ｓｐｅｃｉｆｉｃ　Ｅｍｂｒｙｏｎｉｃ　Ａｎｔｉｇｅｎｓ（ＳＳＥＡ抗原）
  • 初期胚におけるStage-Specific Embryonic Antigens(SSEA抗原)[含 英語文]
  • ショキハイ ニ オケル Stage Specific Embryonic Antigens SSEA コウゲン ガン エイゴブン

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Abstract

In preimplantation embryos, stage-specific embryonic antigen (SSEA)-1, SSEA-3, and SSEA-4 are well-known carbohydrate marker antigens that show a stage-specific expression. SSEA-1 is usually carried by glycoproteins and/or glycolipids, while SSEA-3 and SSEA-4 are mostly carried by glycosphingolipids, which are the major constituents of raft microdomains. Biochemical analysis and confocal laser-scanning microscopic study of raft microdomains have been conducted in cultured cell lines. Here, we show the dynamic movement of SSEA-4 in the raft microdomains of preimplantation mouse embryos by immunostaining with 6E2, a novel anti-SSEA-4 monoclonal antibody, and subsequently discuss the role of raft microdomains in early embryogenesis.<br>

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