Primary central nervous system lymphoma secretes monocyte chemoattractant protein 1
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- KITAI Ryuhei
- Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui
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- ISHISAKA Kazuyo
- Medical Sciences, University of Fukui
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- SATO Kazufumi
- Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui
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- SAKUMA Takahiro
- Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui
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- YAMAUCHI Takahiro
- Medical Sciences, University of Fukui
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- IMAMURA Yoshiaki
- Division of Surgical Pathology, University of Fukui Hospital
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- MATSUMOTO Hideki
- Department of Experimental Radiology and Health Physics, Faculty of Medical Sciences, University of Fukui
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- KUBOTA Toshihiko
- Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui
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抄録
The majority of primary central nervous system lymphomas (PCNSL) are diffuse large B-cell lymphomas. Histologically, reactive T lymphocytes and monohistiocytic cells are found within PCNSL tissue. To clarify the mechanisms of the cellular infiltration, the presence of monocyte chemoattractant protein (MCP-1) was investigated in biopsy samples of 19 cases of PCNSL by means of immunohistochemical staining, double staining with a confocal laser microscope, and Western blot analysis. MCP-1 expression was observed in all PCNSL immunohistochemically. Western blot analysis showed that the concentration of MCP-1 in PCNSL was as high as that in a metastatic brain tumor. In normal brain tissue, MCP-1 was not detected. Confocal laser microscope revealed MCP-1 signals were present in the cells with CD20, a B-cell marker. We concluded that lymphoma cells produced MCP-1, which is an additional cytokine involved in the pathogenesis of PCNSL.
収録刊行物
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- Medical molecular morphology : official journal of the Japanese Society for Clinical Molecular Morphology
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Medical molecular morphology : official journal of the Japanese Society for Clinical Molecular Morphology 40 (1), 18-22, 2007-03-01
Springer
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詳細情報 詳細情報について
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- CRID
- 1571417125697925632
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- NII論文ID
- 10024379375
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- NII書誌ID
- AA12017629
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- ISSN
- 18601480
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles