Primary central nervous system lymphoma secretes monocyte chemoattractant protein 1

IR 1 Citations 24 References
  • KITAI Ryuhei
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui
  • ISHISAKA Kazuyo
    Medical Sciences, University of Fukui
  • SATO Kazufumi
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui
  • SAKUMA Takahiro
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui
  • YAMAUCHI Takahiro
    Medical Sciences, University of Fukui
  • IMAMURA Yoshiaki
    Division of Surgical Pathology, University of Fukui Hospital
  • MATSUMOTO Hideki
    Department of Experimental Radiology and Health Physics, Faculty of Medical Sciences, University of Fukui
  • KUBOTA Toshihiko
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui

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Abstract

The majority of primary central nervous system lymphomas (PCNSL) are diffuse large B-cell lymphomas. Histologically, reactive T lymphocytes and monohistiocytic cells are found within PCNSL tissue. To clarify the mechanisms of the cellular infiltration, the presence of monocyte chemoattractant protein (MCP-1) was investigated in biopsy samples of 19 cases of PCNSL by means of immunohistochemical staining, double staining with a confocal laser microscope, and Western blot analysis. MCP-1 expression was observed in all PCNSL immunohistochemically. Western blot analysis showed that the concentration of MCP-1 in PCNSL was as high as that in a metastatic brain tumor. In normal brain tissue, MCP-1 was not detected. Confocal laser microscope revealed MCP-1 signals were present in the cells with CD20, a B-cell marker. We concluded that lymphoma cells produced MCP-1, which is an additional cytokine involved in the pathogenesis of PCNSL.

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