Rad50 is involved in MMS-induced recombination between homologous chromosomes in mitotic cells

• Tomizawa Yuji

  Molecular Cell Biology Laboratory, Graduate School of Pharmaceutical Sciences, Tohoku University

• Ui Ayako

  Molecular Cell Biology Laboratory, Graduate School of Pharmaceutical Sciences, Tohoku University

• Onoda Fumitoshi

  Molecular Cell Biology Laboratory, Graduate School of Pharmaceutical Sciences, Tohoku University

• Ogiwara Hideaki

  Molecular Cell Biology Laboratory, Graduate School of Pharmaceutical Sciences, Tohoku University

• Tada Shusuke

  Molecular Cell Biology Laboratory, Graduate School of Pharmaceutical Sciences, Tohoku University

• Enomoto Takemi

  Molecular Cell Biology Laboratory, Graduate School of Pharmaceutical Sciences, Tohoku University Tohoku University 21st Century COE Program, “Comprehensive Research and Education Center for Planning of Drug Development and Clinical Evaluation,”

• Seki Masayuki

  Molecular Cell Biology Laboratory, Graduate School of Pharmaceutical Sciences, Tohoku University

抄録

The structural maintenance of chromosomes (SMC) family proteins (Smc1-Smc6) typically consist of two coiled-coil domains, an amino-terminal head domain, and a carboxyl-terminal tail domain. Rad50, a component of the Mre11/Rad50/Xrs2 (MRX) complex, has a similar domain structure to the SMC proteins. In Saccharomyces cerevisiae, the MRX complex appears to be essential for recombination between homologous chromosomes in meiotic cells, but not in cells undergoing vegetative growth. Here we provide for the first time evidence that Rad50, like Smc6, is required for the induction of recombination between homologous chromosomes in cells in the vegetative growth state upon exposure to methyl methanesulfonate. However, UV-induced recombination between homologous chromosomes is intact in both rad50 and smc6-56 mutant cells.<br>

収録刊行物

• Genes & Genetic Systems

  Genes & Genetic Systems 82 (2), 157-160, 2007

  日本遺伝学会

キーワード

• homologous recombination
• Mre11; Rad50; Xrs2; MRX
• Smc5
• Smc6

詳細情報

• CRID: 1390282680449242880
• NII論文ID: 10024394124
• NII書誌ID: AA11077421
• DOI: 10.1266/ggs.82.157
• ISSN: 18805779
• ISSN: 13417568
• NDL書誌ID: 8734756
• Web Site: http://id.ndl.go.jp/bib/8734756
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8734756
• Web Site: http://www.jstage.jst.go.jp/article/ggs/82/2/82_2_157/_pdf
• 本文言語コード: en
• データソース種別:
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