Mosaic genealogy of the Mus musculus genome revealed by 21 nuclear genes from its three subspecies

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Author(s)

Abstract

Patterns of genetic variation provide insight into the evolutionary history of a species. Mouse (<i>Mus musculus</i>) is a good model for this purpose. Here we present the analysis of genealogies of the 21 nuclear loci and one mitochondrial DNA region in <i>M. musculus</i> based on our nucleotide sequences of nine inbred strains from three <i>M. musculus</i> subspecies (<i>musculus</i>, <i>domesticus</i>, and <i>castaneus</i>) and one <i>M. spicilegus</i> strain as an outgroup. The mitochondrial DNA gene genealogy of those strains confirmed the introgression pattern of one <i>musculus</i> strain. When all the nuclear DNA data were concatenated to produce a phylogenetic tree of nine strains, <i>musculus</i> and <i>domesticus</i> strains formed monophyletic clusters with each other, while the two <i>castaneus</i> strains were paraphyletic. When each DNA region was treated independently, the phylogenetic networks revealed an unnegligibly high level of subspecies admixture and the mosaic nature of their genome. Estimation of ancestral and derived population sizes and migration rates suggests the effects of ancestral polymorphism and gene flow on the pattern of genetic variation of the current subspecies. Gene genealogies of <i>Fut4</i> and <i>Dfy </i>loci also suggested existence of the gene flow between <i>M. musculus</i> and <i>M. spicilegus</i> or other distant species.<br>

Journal

  • Genes & Genetic Systems

    Genes & Genetic Systems 83(1), 77-88, 2008-02-25

    The Genetics Society of Japan

References:  58

Cited by:  3

Codes

  • NII Article ID (NAID)
    10024395628
  • NII NACSIS-CAT ID (NCID)
    AA11077421
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    13417568
  • NDL Article ID
    9412495
  • NDL Source Classification
    ZR1(科学技術--生物学)
  • NDL Call No.
    Z53-W539
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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