Sputum Eosinophilia, Airway Hyperresponsiveness and Airway Narrowing in Young Adults with Former Asthma
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- Hara Johsuke
- Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
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- Fujimura Masaki
- Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
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- Myou Shigeharu
- Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
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- Kita Toshiyuki
- Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
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- Abo Miki
- Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
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- Katayama Nobuyuki
- Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
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- Furusho Shiho
- Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
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- Nobata Kouichi
- Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
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- Oribe Yoshitaka
- Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
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- Kimura Hideharu
- Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
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- Sone Takashi
- Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
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- Waseda Yuko
- Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
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- Ichikawa Yukari
- Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
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- Araya Tomoyuki
- Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
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- Ohkura Noriyuki
- Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
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- Tamori Shunichi
- Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
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- Takato Hazuki
- Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
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- Tambo Yuichi
- Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
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- Herai Yoriko
- Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
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- Hori Akihiro
- Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
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- Yasui Masahide
- Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
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- Kasahara Kazuo
- Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
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- Nakao Shinji
- Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
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抄録
Background: 30-80% of outgrown asthma subjects develop symptoms again later in life. We investigated inflammation and function of lower airway in adolescents with former asthma.<br> Methods: 326 never-smoking young adults (mean age 24.0 years) were interviewed with special emphasis on history of asthma. Diagnosis of asthma was based on GINA guidelines. Former asthma subjects consisted of ones with a history of physician-diagnosed childhood asthma, who had been free of asthma symptoms without the use of medication for at least 10 years prior to the study. Provocative concentration of methacholine causing a 20% fall in forced expiratory volume in 1 second (FEV1)(PC20) and eosinophil percentage in induced sputum were measured.<br> Results: 31 subjects were former asthma subjects (FBA), 11 subjects were current asthma subjects (CBA) and 284 subjects had no history of asthma (non-BA). PC20 and FEV1/FVC ratio were significantly lower in the FBA group than in the non-BA group (P < 0.01). Maximal mid-expiratory flow (MMF) was significantly lower in the FBA group than in the non-BA group (P < 0.05). Sputum eosinophil percentage was significantly increased in the FBA group compared with the non-BA group (P < 0.01). PC20 was significantly lower in the CBA group than in the FBA and non-BA groups (P < 0.01). FEV1, FEV1/FVC ratio and MMF were significantly lower in the CBA group than in the FBA group (P < 0.05, P < 0.05 and P < 0.05, respectively) and the non-BA group (P < 0.01, P < 0.01 and P < 0.05, respectively). Sputum eosinophils were significantly higher in the CBA group than in the FBA and non-BA groups (P < 0.01).<br> Conclusions: This study shows that subjects with long-term outgrown asthma continue to have airway eosinophilic inflammation, airway hyperresponsiveness and airway narrowing.<br>
収録刊行物
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- Allergology International
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Allergology International 57 (3), 211-217, 2008
一般社団法人日本アレルギー学会
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詳細情報 詳細情報について
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- CRID
- 1390001204632628096
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- NII論文ID
- 10024419767
- 130004476977
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- NII書誌ID
- AA11091750
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- ISSN
- 14401592
- 13238930
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- PubMed
- 18566550
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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- PubMed
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