Production of Spherical Agglomerates of Cephalosporin Antibiotic Crystals
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- Machiya Koji
- Department of Applied Chemistry and Bioengineering, Graduate School of Engineering, Osaka City University Process Chemistry Laboratories, Astellas Pharma Inc.
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- Koga Keiichi
- Chemical Development Laboratories, Fujisawa Pharmaceutical Co., Ltd. (former)
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- Mukuta Takashi
- Process Chemistry Laboratories, Astellas Pharma Inc.
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- Moriki Shigeru
- Chemical Development Laboratories, Fujisawa Pharmaceutical Co., Ltd. (former)
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- Kagara Kooji
- Chemical Development Laboratories, Fujisawa Pharmaceutical Co., Ltd. (former)
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- Ooshima Hiroshi
- Department of Applied Chemistry and Bioengineering, Graduate School of Engineering, Osaka City University
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Abstract
A cephalosporin antibiotic, PATC (5-Amino-2-[((6R,7R)-7-{(2Z)-2-(5-amino-1,2,4- thiadiazol-3-yl)-2-[(1-carboxy-1-methylethoxy)imino]acetylamino}-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl]-1-(2-hydroxyethyl)-1H-pyrazol-2-iumchloride; MW 632.1 Da), was crystallized by neutralization method, and the spherical agglomeration of micro crystals was obtained to develop a drug for injection. The morphology of agglomerates depended on the initial super-saturation ratio and the presence or absence of seed crystals. Spherical agglomerates were obtained by adding seed crystals of 0.1 wt% under a high initial super-saturation ratio of 130. The compactly packed spherical agglomerates were composed of a number of rod-shape crystals with a uniform length of 60 μm, and had good filtration property. The specific volume of spherical agglomerates was 1.75 cm3/g.
Journal
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- JOURNAL OF CHEMICAL ENGINEERING OF JAPAN
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JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 41 (11), 1017-1023, 2008
The Society of Chemical Engineers, Japan
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Details 詳細情報について
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- CRID
- 1390001204569176064
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- NII Article ID
- 10024448337
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- NII Book ID
- AA00709658
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- ISSN
- 18811299
- 00219592
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- NDL BIB ID
- 9719011
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed