Genetically Determined Thymus Enlargement in the Early Life in BUF/Mna Rats.
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- Saito Mitsuhiro
- Department of Pathology, Nagoya University School of Medicine
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- Amo Hiroyuki
- Aichi Women's College
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- Murakumo Yoshiki
- Department of Pathology, Nagoya University School of Medicine
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- Kojima Akinori
- Nagoya City Public Health Research Institute
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- Katoh Hideki
- Central Institute for Experimental Animals
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- Hiromatsu Takashi
- Department of Pathology, Nagoya University School of Medicine
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- Matsuyama Mutsushi
- Department of Pathology, Fujita Health University School of Medicine
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抄録
BUF/Mna (B) rat is a mutated strain, having much larger thymus than WKY/ NCrj (W), ACI/NMs (A), and F344 (F) rats throughout their life-span. Rats of the latter 3 strains have normal sized thymuses, being less than 5.3 in the thymus to body weight ratio (mg/g), when they were killed at 6 weeks of age. Genetic segregation of large thymus size in the B strain at 6 weeks of age was studied by crossing B rats with W, A or F rats. All of 3 types of the Fl hybrid rats between the B strain and the other strains showed intermediate thymus ratios between those of both parental strains. In F2 rats between the B and W strains, the distribution of thymus ratios showed about 5 different peaks. These findings might indicate that two polymeric autosomal loci, thymus enlargement-1 (Ten-1) and thymus enlargement-2 (Ten-2), can enlarge the thymus size in B rats. Histometrically, whole thymus and cortex areas of the B rats were 2-5 times larger than the W rats during 6-12 weeks of age, but medulla areas were slightly different between the strains, showing that larger thymuses in B rats were mainly due to the enlarged cortex areas.
収録刊行物
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 182 (4), 309-318, 1997
東北ジャーナル刊行会
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詳細情報 詳細情報について
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- CRID
- 1390282679213639168
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- NII論文ID
- 10024507429
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- NII書誌ID
- AA00863920
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- COI
- 1:STN:280:DyaK1c%2Fhtl2iuw%3D%3D
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- ISSN
- 13493329
- 00408727
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- PubMed
- 9352623
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可