ウズラ大腿骨器官培養の骨髄骨形成に及ぼす性ホルモンの影響

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  • Effects of Sex Hormones on Medullary Bone Formation in Cultured Japanese Quail Bones
  • ウズラ ダイタイコツ キカン バイヨウ ノ コツズイコツ ケイセイ ニ オヨボ

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The Effects of estradiol (E2) and testosterone (T) on the proliferation and differentiation of bone lining cells and medullary bone formation were examined in cultured femurs of adult male Japanese quails. On the endosteal surface of bone fragments cultured in fetal calf serum (FCS)-free media with either E2 or T, far more preosteoblasts were observed in comparison with bone fragments before cultivation, Moreover, a great number of preosteoblasts were seen after cultivation with both E2 and T, whereas mitotic figures and osteoblasts were not observed and medullary bone formation did not occur after cultivation in FCS-free media. On the other hand, after cultivation in FCS-containing media with either E2 or T, mitotic figures, osteoblasts, and a small amount of medullary bone were observed. The number of osteoblasts and amount of medullary bone were the greatest in the FCS-containing medium with both E2 and T. These results suggest that E2 and T directly stimulate the differentiation of bone lilning cells into preosteoblasts in the absence of FCS. On the other hand, in the presence of FCS, E2 and T synergistically stimulate the differentiation and proliferation of the bone lining cells into osteoblasts as well as inducing medullary bone formation.

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