Participation of the cholinergic system in ameliorating effect of vasopressin fragment by group 1 metabotropic glutamate-receptor blockade

• Tarumi Tadatsugu

  Department of Medical Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan

• Mikami Azusa

  Department of Medical Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan

• Shimada Kenichi

  Department of Clinical Pharmacy, Shujitsu University School of Pharmacy, Japan

• Kamei Chiaki

  Department of Medical Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan

書誌事項

タイトル別名

• Participation of the Cholinergic System in Ameliorating Effect of Vasopressin Fragment by Group I Metabotropic Glutamate-Receptor Blockade

抄録

The effect of [pGlu⁴,Cyt⁶,Arg⁸]-vasopressin fragment 4-9 (AVP4-9) on group I metabotropic glutamate (mGlu₁) receptor antagonist–induced memory deficits was studied using 8-arm radial maze performance with 4 arms baited. In addition, the participation of the cholinergic system in the ameliorating effect of AVP4-9 on mGlu₁ receptor antagonist–induced memory deficits was also investigated. Intrahippocampal injection of (R,S)-1-aminoindan-1,5-dicarboxylic acid (AIDA), an mGlu₁-receptor antagonist, significantly increased total error, reference memory error, and working memory error at a dose of 20 nmol/side. AVP4-9 (0.1 and 1.0 μg/kg, s.c.) showed a significant ameliorative effect on AIDA-induced memory deficits. Improvement of AIDA-induced memory deficit in response to AVP4-9 treatment was significantly antagonized by scopolamine (5 nmol/side) but not by mecamylamine (200 nmol/side) at a dose that caused no effect on performance when injected separately. These findings indicate that the ameliorating effect of AVP4-9 on AIDA-induced memory deficit may be closely associated with the muscarinic receptor.<br>

収録刊行物

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 108 (3), 335-340, 2008

  公益社団法人 日本薬理学会

キーワード

• [pGlu⁴,Cyt⁶,Arg⁸]-vasopressin fragment 4-9
• group I metabotropic glutamate receptor (mGlu₁)
• 8-arm radial maze
• reference memory error
• working memory error

詳細情報

• CRID: 1390001205180400768
• NII論文ID: 10024593213
• NII書誌ID: AA11806667
• DOI: 10.1254/jphs.08146fp
• ISSN: 13478648
• ISSN: 13478613
• NDL書誌ID: 9719595
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9719595
• Web Site: https://search.jamas.or.jp/link/ui/2009133430
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可