A Biological Experiment in Kibou : LOH Analysis for Estimating the Biological Influences of Space Radiation

• YATAGAI Fumio

  RIKEN Institute Japan Aerospace Exploration Agency

• TAKAHASHI Akihisa

  Nara Pref. Med. Univ.

• HONMA Masamitsu

  Natl. Inst. Health Sci.,

• SUZUKI Hiromi

  Japan Space Forum Kagoshima Univ. Grad. Sch.

• OMORI Katsunori

  Japan Aerospace Exploration Agency

• SEKI Masaya

  Kagoshima Univ. Grad. Sch. Adv. Engineering Services

• HASHIZUME Toko

  Kagoshima Univ. Grad. Sch. Adv. Engineering Services

• SHIMAZU Toru

  Japan Space Forum

• ENOMOTO Shuichi

  RIKEN Institute

• OHNISHI Takeo

  Nara Pref. Med. Univ.

• ISHIOKA Noriaki

  Japan Aerospace Exploration Agency Kagoshima Univ. Grad. Sch.

Bibliographic Information

Other Title

• “きぼう”での生物実験に向けて： LOH 解析による宇宙放射線の生物影響の検討
• キボウ デノ セイブツ ジッケン ニ ムケテ LOH カイセキ ニ ヨル ウチュウ ホウシャセン ノ セイブツ エイキョウ ノ ケントウ

Abstract

This is a kind of review paper to introduce how our developing methodology for loss of heterozygosity (LOH) analysis is predictable to detect the biological effects of space radiation. Our biological experiments using human cultured cells in “Kibou” of International Space Station are planned to detect the following effects: i) mutagenic effects, ii) combined effects of radiation with micro gravity, and iii) radioadaptive response. After the cell recovery to the earth, we will analyze the mutagenic effects (i) in the frozen cells exposed to low-dose space radiation during the 3 months preservation in “Kibou”, determine the combined effects (II) from the mutation inductions in the cells incubated for 1 week under 1G or G in “Kibou”, and estimate the radioadaptive response (iii) from measuring the repair efficiencies of DNA double-strand breaks introduced after the recovery.

Journal

• Journal of The Japan Society of Microgravity Application

  Journal of The Japan Society of Microgravity Application 25 (4), 695-, 2008-10-31

  The Japan Society of Microgravity Application

Details

• CRID: 1390005506400690048
• NII Article ID: 10024595005
• NII Article ID: 130007972350
• NII Book ID: AN10537663
• DOI: 10.15011/jasma.25.4.695
• NDL BIB ID: 9734367
• ISSN: 09153616
• Web Site: http://id.ndl.go.jp/bib/9734367
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9734367
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed