DC-STAMP and Osteoimmunology

• Miyamoto Takeshi

  Department of Orthopedic Surgery, Keio University School of Medicine Department of Musculoskeletal Reconstruction and Regeneration Surgery, Keio University School of Medicine Division of Orthopedic Research, Keio University School of Medicine, Keio University School of Medicine Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency

• Toyama Yoshiaki

  Department of Orthopedic Surgery, Keio University School of Medicine

Abstract

The investigations from the aspect of “osteoimmunology”provided a recent advance on bone cell biology¹⁾. Various molecules identified to play a crucial role in immune system also play a role in bone system. For example, RANK-RANKL system was originally identified in dendritic cells and T cells²⁾, but these molecules are both essential for osteoclast differentiation and skeletal development^3,4). Nuclear factor of activated T cells (NFATc1) was also originally identified in T cells, but plays an essential role in osteoclast differentiation⁵⁾. Thus bone and immune systems share common molecules. Here we introduce a seven transmembrane receptor protein, dendritic cell specific transmembarne protein (DC-STAMP) as an“osteoimmunology”molecule, which plays a role in both bone and immune systems.

Journal

• Inflammation and Regeneration

  Inflammation and Regeneration 29 (1), 59-62, 2009

  The Japanese Society of Inflammation and Regeneration

Keywords

• DC-STAMP
• osteoimmunology
• osteoclasts
• dendritic cells
• cell-cell fusion

Details

• CRID: 1390282680232968192
• NII Article ID: 10024797162
• NII Book ID: AA11508953
• DOI: 10.2492/inflammregen.29.59
• ISSN: 18808190
• ISSN: 18809693
• NDL BIB ID: 10174549
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10174549
• Web Site: https://search.jamas.or.jp/link/ui/2009200916
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed