Expression Pattern of WWP1 in Muscular Dystrophic and Normal Chickens

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  • Matsumoto Hirokazu
    Laboratory of Animal Breeding and Genetics, Graduate School of Agricultural Science, Kobe University, Japan
  • Maruse Hideaki
    Laboratory of Animal Breeding and Genetics, Graduate School of Agricultural Science, Kobe University, Japan
  • Sasazaki Shinji
    Laboratory of Animal Breeding and Genetics, Graduate School of Agricultural Science, Kobe University, Japan
  • Fujiwara Akira
    Laboratory Animal Research Station, Nippon Institute for Biological Science, Japan
  • Takeda Shin'ichi
    Department of Molecular Therapy Japan
  • Ichihara Nobutsune
    Animal Models for Human Disease, National Institute of Neuroscience, NCNP, Japan Department of Anatomy I, School of veterinary medicine, Azabu University, Japan
  • Kikuchi Tateki
    Department of Molecular Therapy Japan
  • Mukai Fumio
    Laboratory of Animal Breeding and Genetics, Graduate School of Agricultural Science, Kobe University, Japan
  • Mannen Hideyuki
    Laboratory of Animal Breeding and Genetics, Graduate School of Agricultural Science, Kobe University, Japan

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The WW domain containing E3 ubiquitin protein ligase 1 (WWP1) is classified into one of ubiquitin ligases which play an important role in ubiquitin-proteasome pathway. Previously, we identified the WWP1 gene as a candidate gene of chicken muscular dystrophy by linkage analysis and sequence comparison. However, the mechanism causing pathological changes and underlaying gene function remains elucidated. In the present study, we analyzed the WWP1 gene expression in various muscles and tissues of normal chickens, and compared with those from muscular dystrophic chickens. Two mRNA isoforms were detected in all tissues examined and revealed almost equal expression level. The WWP1 expression of dystrophic chickens was decreased in almost all skeletal muscles including unaffected muscles. These data indicate that there might not be a causal relationship between the alteration of WWP1 expression level and the severity of muscular dystrophy.

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